Cholesterol transporters in lactating and nonlactating human mammary tissue

Albrecht, C.; Huang, X.; Ontsouka, E. C. (2013). Cholesterol transporters in lactating and nonlactating human mammary tissue. In: Zibadi, S.; Watson, R. R.; Preedy, V. R. (eds.) Handbook of Dietary and Nutritional Aspects of Human Breast Milk. Human Health Handbooks: Vol. 5 (pp. 147-164). Wageningen: Wageningen Academic Publishers 10.3920/978-90-8686-764-6_8

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In mammals milk is the principal nutrient for neonates at birth. The basic milk composition is similar between different mammals, but the content of individual constituents such as lipids may differ significantly from one species to another. The milk fat fraction is mainly composed of triglycerides which account for more than 95% of the lipids found in human and bovine milk. Though sterols and in particular cholesterol, the predominant milk sterol, represent less than 0.5% of the total milk lipid fraction, they are of ultimate importance for biological processes such as the formation of biological membranes or as precursors for steroid hormone synthesis. Cholesterol found in milk originates either from blood uptake or from local synthesis. This chapter provides an overview of cholesterol exchanges between the blood, the mammary tissue and the milk. The current knowledge on the expression, localization and function of candidate cholesterol transporters in mammary tissues of human, murine and bovine origin is summarized. Different mechanisms of how cholesterol can be transferred via the mammary tissue into milk, and which active cholesterol transporters are likely to play a role in this process will be discussed.

Item Type:

Book Section (Book Chapter)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Albrecht, Christiane, Huang, Xiao, Ontsouka, Corneille Edgar


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




Human Health Handbooks


Wageningen Academic Publishers




Patrizia Catucci

Date Deposited:

23 Apr 2014 09:45

Last Modified:

02 Mar 2023 23:24

Publisher DOI:





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