Cholesterol transporters in lactating and nonlactating human mammary tissue

Albrecht, C.; Huang, X.; Ontsouka, E. C. (2013). Cholesterol transporters in lactating and nonlactating human mammary tissue. In: Zibadi, S.; Watson, R. R.; Preedy, V. R. (eds.) Handbook of Dietary and Nutritional Aspects of Human Breast Milk. Human Health Handbooks: Vol. 5 (pp. 147-164). Wageningen: Wageningen Academic Publishers 10.3920/978-90-8686-764-6_8

[img]
Preview
Text
handbook of dietary and nutritional aspects.pdf - Published Version
Available under License Publisher holds Copyright.

Download (868kB) | Preview

In mammals milk is the principal nutrient for neonates at birth. The basic milk composition is similar between different mammals, but the content of individual constituents such as lipids may differ significantly from one species to another. The milk fat fraction is mainly composed of triglycerides which account for more than 95% of the lipids found in human and bovine milk. Though sterols and in particular cholesterol, the predominant milk sterol, represent less than 0.5% of the total milk lipid fraction, they are of ultimate importance for biological processes such as the formation of biological membranes or as precursors for steroid hormone synthesis. Cholesterol found in milk originates either from blood uptake or from local synthesis. This chapter provides an overview of cholesterol exchanges between the blood, the mammary tissue and the milk. The current knowledge on the expression, localization and function of candidate cholesterol transporters in mammary tissues of human, murine and bovine origin is summarized. Different mechanisms of how cholesterol can be transferred via the mammary tissue into milk, and which active cholesterol transporters are likely to play a role in this process will be discussed.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Albrecht, Christiane; Huang, Xiao and Ontsouka, Edgar

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISBN:

978-90-8686-209-2

Series:

Human Health Handbooks

Publisher:

Wageningen Academic Publishers

Language:

English

Submitter:

Patrizia Catucci

Date Deposited:

23 Apr 2014 09:45

Last Modified:

28 Dec 2014 06:53

Publisher DOI:

10.3920/978-90-8686-764-6_8

BORIS DOI:

10.7892/boris.43294

URI:

https://boris.unibe.ch/id/eprint/43294

Actions (login required)

Edit item Edit item
Provide Feedback