SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters

Bergeron, M. J.; Clémençon, B.; Hediger, M. A.; Markovich, D. (2013). SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters. Molecular aspects of medicine, 34(2-3), pp. 299-312. Elsevier 10.1016/j.mam.2012.12.001

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The SLC13 family comprises five genes (SLC13A1, SLC13A2, SLC13A3, SLC13A4, and SLC13A5) encoding structurally related multi-spanning transporters (8-13 transmembrane domains) with orthologues found in prokaryotes and eukaryotes. Mammalian SLC13 members mediate the electrogenic Na(+)-coupled anion cotransport at the plasma membrane of epithelial cells (mainly kidney, small intestine, placenta and liver) or cells of the central nervous system. While the two SLC13 cotransporters NaS1 (SLC13A1) and NaS2 (SLC13A4) transport anions such sulfate, selenate and thiosulfate, the three other SLC13 members, NaDC1 (SLC13A2), NaCT (SLC13A5) and NaDC3 (SLC13A3), transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and α-ketoglutarate. All these transporters play a variety of physiological and pathophysiological roles in the different organs. Thus, the purpose of this review is to summarize the roles of SLC13 members in human physiology and pathophysiology and what the therapeutic perspectives are. We have also described the most recent advances on the structure, expression, function and regulation of SLC13 transporters.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Clemençon, Benjamin and Hediger, Matthias


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Patrizia Catucci

Date Deposited:

01 May 2014 12:35

Last Modified:

01 May 2014 12:35

Publisher DOI:


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