van der Hoeven, N W; Teunissen, P F; Werner, G S; Delewi, R; Schirmer, S H; Traupe, Tobias; van der Laan, A M; Tijssen, J G; Piek, J J; Seiler, Christian; van Royen, N (2013). Clinical parameters associated with collateral development in patients with chronic total coronary occlusion. Heart, 99(15), pp. 1100-1105. BMJ Publishing Group 10.1136/heartjnl-2013-304006
Full text not available from this repository.OBJECTIVE
Well-developed collaterals provide survival benefit in patients with obstructive coronary artery disease (CAD). Therefore, in this study we sought to determine which clinical variables are associated with arteriogenesis.
DESIGN
Clinical and laboratory variables were collected before percutaneous coronary intervention. Multivariate analysis was performed to determine which variables are associated with the collateral flow index (CFI).
PATIENTS
Data from 295 chronic total occlusion (CTO) patients (Bern, Switzerland, Amsterdam, the Netherlands and Jena, Germany) were pooled. In earlier studies, patients had varying degrees of stenosis. Therefore, different stages of development of the collaterals were used. In our study, a unique group of patients with CTO was analysed.
INTERVENTIONS
Instead of angiography used earlier, we used a more accurate method to determine CFI using intracoronary pressure measurements. CFI was calculated from the occlusive pressure distal of the coronary lesion, the aortic pressure and central venous pressure.
RESULTS
The mean CFI was 0.39 ± 0.14. After multivariate analysis, β blockers, hypertension and angina pectoris duration were positively associated with CFI (B: correlation coefficient β=0.07, SE=0.03, p=0.02, B=0.040, SE=0.02, p=0.042 and B=0.001, SE=0.000, p=0.02). Furthermore also after multivariate analysis, high serum leucocytes, prior myocardial infarction and high diastolic blood pressure were negatively associated with CFI (B=-0.01, SE=0.005, p=0.03, B=-0.04, SE=0.02, p=0.03 and B=-0.002, SE=0.001, p=0.011).
CONCLUSIONS
In this unique cohort, high serum leucocytes and high diastolic blood pressure are associated with poorly developed collaterals. Interestingly, the use of β blockers is associated with well-developed collaterals, shedding new light on the potential action mode of this drug in patients with CAD.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Traupe, Tobias, Seiler, Christian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1355-6037 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
PD Dr. Tobias Traupe |
Date Deposited: |
24 Mar 2014 10:40 |
Last Modified: |
05 Dec 2022 14:29 |
Publisher DOI: |
10.1136/heartjnl-2013-304006 |
PubMed ID: |
23716567 |
URI: |
https://boris.unibe.ch/id/eprint/43355 |
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