Oral contraceptives and the risk of thrombosis and atherosclerosis.

Barton, Matthias; Dubey, Raghvendra K; Traupe, Tobias (2002). Oral contraceptives and the risk of thrombosis and atherosclerosis. Expert opinion on investigational drugs, 11(3), pp. 329-332. Informa Healthcare 10.1517/13543784.11.3.329

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Oral contraceptives containing synthetic oestrogens have been used successfully as birth control for > 40 years and are currently prescribed to > 100 million women worldwide. Several new progestins have been introduced and the third generation of progestins has now been available for two decades. Oral contraceptives are prescribed over a prolonged period of time and therefore substantially impact on hormonal, metabolic and plasmatic functions. Oral contraceptives increase the risk for venous thrombosis and pulmonary embolism, particularly if associated with confounding factors, such as genetic predisposition, smoking, hypertension or obesity. The risk of developing coronary artery disease is also increased in users with cardiovascular risk factors. This article discusses mechanistic and clinical issues and reviews the need for novel approaches targeting the considerable side effects in order to reduce cardiovascular morbidity in women using oral contraceptives.

Item Type:	Journal Article (Review Article)
UniBE Contributor:	Traupe, Tobias
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1354-3784
Publisher:	Informa Healthcare
Language:	English
Submitter:	PD Dr. Tobias Traupe
Date Deposited:	23 Jul 2014 16:39
Last Modified:	05 Dec 2022 14:29
Publisher DOI:	10.1517/13543784.11.3.329
PubMed ID:	11866662
URI:	https://boris.unibe.ch/id/eprint/43381