The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus

Takes, Robert P.; Ferlito, Alfio; Silver, Carl E.; Rinaldo, Alessandra; Medina, Jesus E.; Robbins, K. Thomas; Rodrigo, Juan P.; Hamoir, Marc; Suárez, Carlos; Zbären, Peter; Mondin, Vanni; Shaha, Ashok R.; Mendenhall, William M.; Strojan, Primož (2014). The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus. European archives of oto-rhino-laryngology, 271(5), pp. 899-904. Springer 10.1007/s00405-013-2591-0

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Squamous cell carcinoma (SCC) of the maxillary sinus is a relatively rare disease. As the reported incidence of regional metastasis varies widely, controversy exists as to whether or not the N0 classified neck should be treated electively. In this review, the data from published series are analyzed to decide on a recommendation of elective treatment of the neck in maxillary SCC. The published series consist of heterogeneous populations of different subsites of the paranasal sinuses, different histological types, different staging and treatment modalities used and different ways of reporting the results. These factors do not allow for recommendations based on high levels of evidence. Given this fact, the relatively high incidence rate of regional metastasis at presentation or in follow-up in the untreated N0 neck, and the relatively low toxicity of elective neck irradiation, such irradiation in SCC of the maxillary sinus should be considered.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Zbären, Peter


600 Technology > 610 Medicine & health








Lilian Tschan

Date Deposited:

07 Mar 2014 09:46

Last Modified:

16 Nov 2015 10:25

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Maxillary sinus, Squamous cell carcinoma, Head and neck cancer, Elective neck treatment




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