Monitoring of Urinary Calcium and Phosphorus Excretion in Preterm Infants - Comparison of two Methods

Staub, Eveline; Wiedmer, Nicolas; Staub, Lukas P.; Nelle, Mathias; von Vigier, Rodo O. (2014). Monitoring of Urinary Calcium and Phosphorus Excretion in Preterm Infants - Comparison of two Methods. Journal of pediatric gastroenterology and nutrition, 58(4), pp. 404-408. Lippincott Williams & Wilkins 10.1097/MPG.0000000000000244

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OBJECTIVES: Premature babies require supplementation with calcium and phosphorus to prevent metabolic bone disease of prematurity. To guide mineral supplementation, two methods of monitoring urinary excretion of calcium and phosphorus are used: urinary calcium or phosphorus concentration and calcium/creatinine or phosphorus/creatinine ratios. We compare these two methods in regards to their agreement on the need for mineral supplementation. METHODS: Retrospective chart review of 230 premature babies with birthweight <1500 g, undergoing screening of urinary spot samples from day 21 of life and fortnightly thereafter. Hypothetical cut-off values for urine calcium or phosphorus concentration (1 mmol/l) and urine calcium/creatinine ratio (0.5 mol/mol) or phosphorus/creatinine ratio (4 mol/mol) were applied to the sample results. The agreement on whether or not to supplement the respective minerals based on the results with the two methods was compared. Multivariate general linear models sought to identify patient characteristic to predict disagreeing results. RESULTS: 24.8% of cases disagreed on the indication for calcium supplementation, 8.8% for phosphorus. Total daily calcium intake was the only patient characteristic associated with discordant results. CONCLUSIONS: With the intention to supplement the respective mineral, comparison of urinary mineral concentration with mineral/creatinine ratio is moderate for Calcium and good for Phosphorus. The results do not allow to identify superiority of either method on the decision which babies require calcium and/or phosphorus supplements.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Evaluative Research into Orthopaedic Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neonatology

UniBE Contributor:

Staub, Lukas and Nelle, Mathias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0277-2116

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Mathias Nelle

Date Deposited:

23 Jul 2014 16:54

Last Modified:

22 Oct 2015 13:57

Publisher DOI:

10.1097/MPG.0000000000000244

PubMed ID:

24253368

BORIS DOI:

10.7892/boris.43497

URI:

https://boris.unibe.ch/id/eprint/43497

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