Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature

Schick, Ulrike; Pusztaszeri, Marc; Betz, Michael; Ghadjar, Pirus; Demiroz, Candan; Kaanders, Johannes H. A. M.; Ozsahin, Mahmut (2013). Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature. Oral surgery, oral medicine, oral pathology and oral radiology, 116(3), pp. 313-320. Elsevier 10.1016/j.oooo.2013.05.003

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PURPOSE

To assess the clinical profile and prognostic factors in patients with adenosquamous carcinoma (ASC) of the head and neck treated by surgery and/or radiation therapy with or without chemotherapy.

METHODS

Data from 20 patients with stage I-II (n = 4), III (n = 5), or IVA (n = 11) head and neck ASC, treated between 1989 and 2010 were collected in a retrospective multicenter Rare Cancer Network study. Surgery was performed in 16 patients. Seventeen patients received combined modality treatment.

RESULTS

After a median follow-up of 15.5 months, 12 patients recurred. The 3-year and median overall survival, disease-free survival (DFS), and loco-regional control were 52% and 39 months, 32% and 12 months, and 47% and 33 months respectively. In multivariate analysis, DFS was negatively influenced by the presence of extracapsular extension and advanced stage.

CONCLUSION

Overall prognosis of locoregionally advanced ASC remains poor. However, early stage ASC patients managed with combined modality treatment may have prolonged DFS.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
UniBE Contributor:	Ghadjar, Pirus
Subjects:	600 Technology > 610 Medicine & health
ISSN:	2212-4411
Publisher:	Elsevier
Language:	English
Submitter:	Beatrice Scheidegger
Date Deposited:	23 Apr 2014 11:34
Last Modified:	05 Dec 2022 14:29
Publisher DOI:	10.1016/j.oooo.2013.05.003
PubMed ID:	23850369
URI:	https://boris.unibe.ch/id/eprint/43515