Cis-retinoids and the chemistry of vision

Cascella, Michele; Bärfuss, Simon; Stocker, Achim (2013). Cis-retinoids and the chemistry of vision. Archives of biochemistry and biophysics, 539(2), pp. 187-195. Elsevier 10.1016/j.abb.2013.06.003

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We discuss here principal biochemical transformations of retinoid molecules in the visual cycle. We focus our analysis on the accumulating evidence of alternate pathways and functional redundancies in the cycle. The efficiency of the visual cycle depends, on one hand, on fast regeneration of the photo-bleached chromophores. On the other hand, it is crucial that the cyclic process should be highly selective to avoid accumulation of byproducts. The state-of-the-art knowledge indicates that single enzymatically active components of the cycle are not strictly selective and may require chaperones to enhance their rates. It appears that protein–protein interactions significantly improve the biological stability of the visual cycle. In particular, synthesis of thermodynamically less stable 11-cis-retinoid conformers is favored by physical interactions of the isomerases present in the retina with cellular retinaldehyde binding protein

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Cascella, Michele and Stocker, Achim

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0003-9861

Publisher:

Elsevier

Language:

English

Submitter:

Achim Stocker

Date Deposited:

12 Mar 2014 10:40

Last Modified:

31 Aug 2015 08:25

Publisher DOI:

10.1016/j.abb.2013.06.003

BORIS DOI:

10.7892/boris.43799

URI:

https://boris.unibe.ch/id/eprint/43799

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