Catheter removal versus retention in the management of catheter-associated enterococcal bloodstream infections

Marschall, Jonas; Piccirillo, Marilyn L; Fraser, Victoria J; Doherty, Joshua A; Warren, David K (2013). Catheter removal versus retention in the management of catheter-associated enterococcal bloodstream infections. Canadian Journal of Infectious Diseases & Medical Microbiology, 24(3), e83-e87. Pulsus

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BACKGROUND

Enterococci are an important cause of central venous catheter (CVC)-associated bloodstream infections (CA-BSI). It is unclear whether CVC removal is necessary to successfully manage enterococcal CA-BSI.

METHODS

A 12-month retrospective cohort study of adults with enterococcal CA-BSI was conducted at a tertiary care hospital; clinical, microbiological and outcome data were collected.

RESULTS

A total of 111 patients had an enterococcal CA-BSI. The median age was 58.2 years (range 21 to 94 years). There were 45 (40.5%) infections caused by Entercoccus faecalis (among which 10 [22%] were vancomycin resistant), 61 (55%) by Enterococcus faecium (57 [93%] vancomycin resistant) and five (4.5%) by other Enterococcus species. Patients were treated with linezolid (n=51 [46%]), vancomycin (n=37 [33%]), daptomycin (n=11 [10%]), ampicillin (n=2 [2%]) or quinupristin/dalfopristin (n=2 [2%]); seven (n=6%) patients did not receive adequate enterococcal treatment. Additionally, 24 (22%) patients received adjunctive gentamicin treatment. The CVC was retained in 29 (26.1%) patients. Patients with removed CVCs showed lower rates of in-hospital mortality (15 [18.3%] versus 11 [37.9]; P=0.03), but similar rates of recurrent bacteremia (nine [11.0%] versus two (7.0%); P=0.7) and a similar post-BSI length of hospital stay (median days [range]) (11.1 [1.7 to 63.1 days] versus 9.3 [1.9 to 31.8 days]; P=0.3). Catheter retention was an independent predictor of mortality (OR 3.34 [95% CI 1.21 to 9.26]).

CONCLUSIONS

To the authors' knowledge, the present article describes the largest enterococcal CA-BSI series to date. Mortality was increased among patients who had their catheter retained. Additional prospective studies are necessary to determine the optimal management of enterococcal CA-BSI.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
UniBE Contributor:	Marschall, Jonas
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1712-9532
Publisher:	Pulsus
Language:	English
Submitter:	Annelies Luginbühl
Date Deposited:	21 Mar 2014 10:27
Last Modified:	05 Dec 2022 14:29
PubMed ID:	24421837
Uncontrolled Keywords:	Bacteremia, Central venous catheter, Enterococcus, Management
URI:	https://boris.unibe.ch/id/eprint/43807