Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system

Vanden Bergh, Philippe; Frey, Joachim (2013). Aeromonas salmonicida subsp. salmonicida in the light of its type-three secretion system. Microbial biotechnology, 7(5), pp. 381-400. Wiley 10.1111/1751-7915.12091

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Aeromonas salmonicida subsp. salmonicida is an important pathogen in salmonid aquaculture and is responsible for the typical furunculosis. The type-three secretion system (T3SS) is a major virulence system. In this work, we review structure and function of this highly sophisticated nanosyringe in A. salmonicida. Based on the literature as well as personal experimental observations, we document the genetic (re)organization, expression regulation, anatomy, putative functional origin and roles in the infectious process of this T3SS. We propose a model of pathogenesis where A. salmonicida induces a temporary immunosuppression state in fish in order to acquire free access to host tissues. Finally, we highlight putative important therapeutic and vaccine strategies to prevent furunculosis of salmonid fish.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology

UniBE Contributor:

Frey, Joachim

Subjects:

600 Technology > 630 Agriculture

ISSN:

1751-7915

Publisher:

Wiley

Language:

English

Submitter:

Susanne Portner

Date Deposited:

22 Aug 2014 13:39

Last Modified:

11 Feb 2015 14:25

Publisher DOI:

10.1111/1751-7915.12091

PubMed ID:

24119189

BORIS DOI:

10.7892/boris.43842

URI:

https://boris.unibe.ch/id/eprint/43842

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