Inheritance of ectopic ureters in Entlebucher Mountain Dogs

Fritsche, R.; Dolf, Gaudenz; Schelling, C.; Hungerbuehler, S. O.; Hagen, R.; Reichler, I. M. (2014). Inheritance of ectopic ureters in Entlebucher Mountain Dogs. Journal of animal breeding and genetics, 131(2), pp. 146-152. Wiley-Blackwell 10.1111/jbg.12055

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To test the hypothesis of a heritable base of ectopic ureters (EU) in Entlebucher Mountain Dogs (EMD) and to elucidate associated risk factors and mode of inheritance of the disease, 565 EMD were clinically investigated and population genetic analyses performed. Based on the location of the most caudal termination of the ureteral openings, 552 EMD were classified into three phenotype groups trigone, intravesically and extravesically ectopic based on results of abdominal sonography, urethra-cystoscopy and/or contrast-enhanced computed tomography. One-third (32.9%) of the phenotyped animals had normal terminations of both ureters in the bladder trigone, 47.3% had at least one intravesicular ectopic termination and 19.8% had at least one extravesicular ectopic termination. Multivariate mixed logistic regression revealed gender as a risk factor associated with EU as males were more often affected than females. Complex segregation analysis indicated a hereditary basis for EU in EMD and the involvement of a major gene in the occurrence of the extravesicular EU phenotype.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Dolf, Gaudenz

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0931-2668

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Susanne Portner

Date Deposited:

28 Jul 2014 09:15

Last Modified:

14 Oct 2015 11:12

Publisher DOI:

10.1111/jbg.12055

PubMed ID:

24628724

Uncontrolled Keywords:

Ureteral ectopia, population genetics, canine, breeding selection, ureteral orifice

URI:

https://boris.unibe.ch/id/eprint/43920

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