Hijacking of Host Cell Signaling by Theileria

Woods, Kerry; von Schubert, Conrad; Dobbelaere, Dirk, (2013). Hijacking of Host Cell Signaling by Theileria. In: Doerig, Christian; Späth, Gerald; Wiese, Martin (eds.) Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. Drug discovery in infectious diseases: Vol. 5 (pp. 179-198). Weinheim: Wiley-VCH 10.1002/9783527675401.ch09

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The apicomplexan parasites Theileria annulata and T. parva possess the ability to transform the infected host cell and induce uncontrolled proliferation. Residing free in the cytosol of its host leukocyte, the schizont is in a perfect position to manipulate host cell signaling pathways involved in regulating apoptosis, proliferation, and cell motility. While extensive Theileria-induced changes in host cell protein phosphorylation patterns have been reported, no Theileria-encoded kinases or phosphatases have been demonstrated - or are even predicted - to be associated with the schizont surface or secreted into the host cell. Instead, it seems that Theileria has evolved the capacity to modulate kinases of the host cell. In certain cases this involves “hijacking” pivotal kinases, such as the IκB kinase complex or the mitotic kinase polo-like kinase 1, recruiting them to the schizont surface. In this chapter the current understanding of Theileria-induced changes in host cell kinase activation is reviewed, and an attempt is made to link these events to phenotypic changes that occur in the cell in response to Theileria infection.

Item Type:

Book Section (Book Chapter)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Molecular Pathobiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Woods, Kerry and Dobbelaere, Dirk,

Subjects:

600 Technology > 630 Agriculture

ISBN:

978-3-527-33235-9

Series:

Drug discovery in infectious diseases

Publisher:

Wiley-VCH

Language:

English

Submitter:

Susanne Portner

Date Deposited:

28 Jul 2014 12:08

Last Modified:

13 Feb 2015 07:31

Publisher DOI:

10.1002/9783527675401.ch09

Uncontrolled Keywords:

Theileria spp, phosphorylation, transformation, kinase, Apicomplexa, parasite

URI:

https://boris.unibe.ch/id/eprint/43934

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