Preventing erosion with novel agents

Wang, Xiaojie; Megert, Brigitte; Hellwig, Elmar; Neuhaus, Klaus; Lussi, Adrian (2011). Preventing erosion with novel agents. Journal of dentistry, 39(2), pp. 163-170. Oxford: Elsevier Science 10.1016/j.jdent.2010.11.007

[img] Text
1-s2.0-S0300571210002812-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (507kB) | Request a copy

Objectives: This in vitro study aimed to investigate the protective effect of four commercial novel agents against erosion.

Methods: Ninety human molars were distributed into 9 groups, and after incubation in human saliva for 2 h, a pellicle was formed. Subsequently, the specimens were submitted to demineralization (orange juice, pH 3.6, 3 min) and remineralization (paste slurry containing one of the tested novel agents, 3 min) cycles, two times per day, for 4 days. The tested agents were: (1) DenShield Tooth; active ingredient: 7.5% W/W NovaMin® (calcium sodium phosphosilicate); (2) Nanosensitive hca; active ingredient: 7.5% W/W NovaMin®; (3) GC Tooth Mousse; active ingredient: 10% Recaldent™ (CPP-ACP); (4) GC MI Paste Plus; active ingredients: 10% Recaldent™, 900 ppm fluoride. Two experimental procedures were performed: in procedure 1, the tested agents were applied prior to the erosive attack, and in procedure 2 after the erosive attack. A control group receiving no prophylactic treatment was included. Surface nanohardness (SNH) of enamel specimens was measured after pellicle formation and after completion of daily cyclic treatment.

Results: SNH significantly decreased at the end of the experiment for all groups (p < 0.05). In both procedures, there was no statistically significant difference between the control group and those treated with paste slurries (p > 0.05). In addition, the changes in SNH (ΔSNH = SNHbaseline − SNHfinal) did not show statistically significant difference between both procedures (p > 0.05).

Conclusion: Tooth erosion cannot be prevented or repaired by these novel agents, regardless of fluoride content.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry
04 Faculty of Medicine > School of Dental Medicine > Division of Fixed Prosthodontics [discontinued]

UniBE Contributor:

Wang, Xiaojie; Megert, Brigitte; Neuhaus, Klaus and Lussi, Adrian


600 Technology > 610 Medicine & health




Elsevier Science




Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:16

Last Modified:

25 Jan 2017 12:16

Publisher DOI:


PubMed ID:


Web of Science ID:




URI: (FactScience: 208591)

Actions (login required)

Edit item Edit item
Provide Feedback