Difficult to control atopic dermatitis

Darsow, Ulf; Wollenberg, Andreas; Simon, Dagmar; Taïeb, Alain; Werfel, Thomas; Oranje, Arnold; Svensson, Ake; Deleuran, Mette; Gelmetti, Carlo; Calza, Anne-Marie; Giusti, Francesca; Lübbe, Jann; Seidenari, Stefania; Ring, Johannes; European Task Force on Atopic Dermatitis / EADV Eczema Task, the (2013). Difficult to control atopic dermatitis. World Allergy Organization journal, 6(1), p. 6. BioMed Central 10.1186/1939-4551-6-6

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Difficult to control atopic dermatitis (AD) presents a therapeutic challenge and often requires combinations of topical and systemic treatment. Anti-inflammatory treatment of severe AD most commonly includes topical glucocorticosteroids and topical calcineurin antagonists used for exacerbation management and more recently for proactive therapy in selected cases. Topical corticosteroids remain the mainstay of therapy, the topical calcineurin inhibitors tacrolimus and pimecrolimus are preferred in certain locations. Systemic anti-inflammatory treatment is an option for severe refractory cases. Microbial colonization and superinfection contribute to disease exacerbation and thus justify additional antimicrobial / antiseptic treatment. Systemic antihistamines (H1) may relieve pruritus but do not have sufficient effect on eczema. Adjuvant therapy includes UV irradiation preferably of UVA1 wavelength. "Eczema school" educational programs have been proven to be helpful.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1939-4551

Publisher:

BioMed Central

Language:

English

Submitter:

Monika Schenk

Date Deposited:

15 May 2014 11:22

Last Modified:

26 Jun 2016 01:48

Publisher DOI:

10.1186/1939-4551-6-6

PubMed ID:

23663504

BORIS DOI:

10.7892/boris.44073

URI:

https://boris.unibe.ch/id/eprint/44073

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