Immunohistochemical evaluation of heat shock protein expression in normal canine nerve and peripheral nerve sheath tumours

Romanucci, M.; Berardi, I.; Ciccarelli, A.; Bongiovanni, L.; Malatesta, D.; Oevermann, Anna; Della Salda, L. (2013). Immunohistochemical evaluation of heat shock protein expression in normal canine nerve and peripheral nerve sheath tumours. Journal of comparative pathology, 149(2-3), pp. 216-220. Elsevier 10.1016/j.jcpa.2012.11.240

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Abnormal expression of heat shock proteins (HSPs) has been observed in many human neoplasms and such expression has prognostic, predictive and therapeutic implications. The aim of this study was to evaluate immunohistochemically the expression of HSP 27, HSP 32 and HSP 90 in normal canine peripheral nerves and in four benign and 15 malignant canine peripheral nerve sheath tumours (PNSTs). In normal nerve, all of the HSPs were detected in axons, epineurial fibroblasts and scattered Schwann cell bodies. Cytoplasmic expression of HSP 27 was more widespread and intense in benign PNSTs compared with malignant PNSTs (P <0.05). Widespread and intense nuclear expression of HSP 32 was also associated with benign tumours (P <0.01), while high HSP 90 immunoreactivity was detected in all tumours, suggesting that HSP 90 might represent a new therapeutic target.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Oevermann, Anna

Subjects:

600 Technology > 630 Agriculture

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Susanne Portner

Date Deposited:

28 Jul 2014 11:02

Last Modified:

12 Feb 2015 10:48

Publisher DOI:

10.1016/j.jcpa.2012.11.240

PubMed ID:

23348018

Uncontrolled Keywords:

dog, heat shock protein, immunohistochemistry, peripheral nerve sheath tumour

URI:

https://boris.unibe.ch/id/eprint/44078

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