[Concurrent irradiation and DNA tumor vaccination in canine oral malignant melanoma: a pilot study].

Herzog, A.; Buchholz, J.; Ruess-Melzer, K; Lang, Johann; Kaser-Hotz, B. (2013). [Concurrent irradiation and DNA tumor vaccination in canine oral malignant melanoma: a pilot study]. Schweizer Archiv für Tierheilkunde, 155(2), pp. 135-142. Huber 10.1024/0036-7281/a000430

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Melanoma is the most common oral tumor in dogs, characterized by rapid growth, local invasion, and high metastatic rate. The goal of this study was to evaluate the combination of radiation therapy and DNA tumor vaccine. We hypothesized, that the concurrent use would not increase toxicity. Nine dogs with oral melanoma were treated with 4 fractions of 8 Gray at 7-day intervals. The vaccine was given 4 times every 14 days, beginning at the first radiation fraction. Local acute radiation toxicities were assessed according to the VRTOG toxicity scoring scheme over a time period of 7 weeks. In none of the evaluated dogs, mucositis, dermatitis and conjunctivitis exceeded grade 2. In 3 dogs mild fever, lethargy, and local swelling at the injection site were seen after vaccine application. In conclusion, the concurrent administration of radiation therapy and vaccine was well tolerated in all dogs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology

UniBE Contributor:

Lang, Johann

ISSN:

0036-7281

Publisher:

Huber

Language:

German

Submitter:

Susanne Portner

Date Deposited:

04 Jul 2014 15:15

Last Modified:

04 Jul 2014 15:15

Publisher DOI:

10.1024/0036-7281/a000430

PubMed ID:

23385072

URI:

https://boris.unibe.ch/id/eprint/44092

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