Impact of different breathing protocols on multiple-breath washout outcomes in children

Yammine, Sophie; Singer, Florian; Gustafsson, Per; Latzin, Philipp (2014). Impact of different breathing protocols on multiple-breath washout outcomes in children. Journal of cystic fibrosis, 13(2), pp. 190-197. Elsevier 10.1016/j.jcf.2013.08.010

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BACKGROUND To standardize multiple-breath washout (MBW) measurements, 1L tidal volume (VT) protocols were suggested. The effect on MBW derived ventilation inhomogeneity (VI) indices is unclear. METHODS We compared VI indices from free breathing MBW at baseline to 1L VT MBW performed in triplicates in 35 children (20 with CF). Mean (range) age was 12.8 (7.0-16.7) years, weight 42 (20-64) kg and height 151 (117-170) cm. RESULTS Baseline lung clearance index (LCI) increased from mean (SD) 11.0 (2.2) to 13.0 (2.6), p=0.011, in CF and from 6.8 (0.5) to 7.7 (1.4), p=0.004, in controls. Moment ratio and Scond similarly increased. While change in VI indices was heterogeneous in individuals, decrease in functional residual capacity was most strongly associated with LCI increase. CONCLUSION MBW protocols strongly influence measures of VI. The 1L VT MBW protocol leads to overestimation of VI and is not recommended in children.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)

UniBE Contributor:

Yammine, Sophie; Singer, Florian and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1569-1993

Publisher:

Elsevier

Language:

English

Submitter:

André Schaller

Date Deposited:

24 Jul 2014 17:42

Last Modified:

29 Oct 2015 10:18

Publisher DOI:

10.1016/j.jcf.2013.08.010

PubMed ID:

24075581

Uncontrolled Keywords:

Children, Clinical use, Cystic fibrosis, Lung physiology, Respiratory function test

BORIS DOI:

10.7892/boris.44134

URI:

https://boris.unibe.ch/id/eprint/44134

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