Randomization in clinical trials in orthodontics: its significance in research design and methods to achieve it

Pandis, Nikolaos; Polychronopoulou, Argy; Eliades, Theodore (2011). Randomization in clinical trials in orthodontics: its significance in research design and methods to achieve it. European journal of orthodontics, 33(6), pp. 684-90. Oxford: Oxford University Press 10.1016/j.ejvs.2006.12.010

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Randomization is a key step in reducing selection bias during the treatment allocation phase in randomized clinical trials. The process of randomization follows specific steps, which include generation of the randomization list, allocation concealment, and implementation of randomization. The phenomenon in the dental and orthodontic literature of characterizing treatment allocation as random is frequent; however, often the randomization procedures followed are not appropriate. Randomization methods assign, at random, treatment to the trial arms without foreknowledge of allocation by either the participants or the investigators thus reducing selection bias. Randomization entails generation of random allocation, allocation concealment, and the actual methodology of implementing treatment allocation randomly and unpredictably. Most popular randomization methods include some form of restricted and/or stratified randomization. This article introduces the reasons, which make randomization an integral part of solid clinical trial methodology, and presents the main randomization schemes applicable to clinical trials in orthodontics.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Pandis, Nikolaos

ISSN:

0141-5387

Publisher:

Oxford University Press

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:16

Last Modified:

25 Jan 2017 12:16

Publisher DOI:

10.1016/j.ejvs.2006.12.010

PubMed ID:

21320892

Web of Science ID:

000247217500009

URI:

https://boris.unibe.ch/id/eprint/4418 (FactScience: 208620)

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