Impact of Antiviral Preventive Strategies on the Incidence and Outcomes of Cytomegalovirus Disease in Solid Organ Transplant Recipients

Manuel, O.; Kralidis, G.; Mueller, N. J.; Hirsch, H. H.; Garzoni, C.; van Delden, C.; Berger, C.; Boggian, K.; Cusini, A.; Koller, M. T.; Weisser, M.; Pascual, M.; Meylan, P. R. (2013). Impact of Antiviral Preventive Strategies on the Incidence and Outcomes of Cytomegalovirus Disease in Solid Organ Transplant Recipients. American journal of transplantation, 13(9), pp. 2402-2410. Wiley-Blackwell 10.1111/ajt.12388

[img] Text
ajt12388.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (284kB) | Request a copy

We assessed the impact of antiviral prophylaxis and preemptive therapy on the incidence and outcomes of cytomegalovirus (CMV) disease in a nationwide prospective cohort of solid organ transplant recipients. Risk factors associated with CMV disease and graft failure-free survival were analyzed using Cox regression models. One thousand two hundred thirty-nine patients transplanted from May 2008 until March 2011 were included; 466 (38%) patients received CMV prophylaxis and 522 (42%) patients were managed preemptively. Overall incidence of CMV disease was 6.05% and was linked to CMV serostatus (D+/R− vs. R+, hazard ratio [HR] 5.36 [95% CI 3.14–9.14], p < 0.001). No difference in the incidence of CMV disease was observed in patients receiving antiviral prophylaxis as compared to the preemptive approach (HR 1.16 [95% CI 0.63–2.17], p = 0.63). CMV disease was not associated with a lower graft failure-free survival (HR 1.27 [95% CI 0.64–2.53], p = 0.50). Nevertheless, patients followed by the preemptive approach had an inferior graft failure-free survival after a median of 1.05 years of follow-up (HR 1.63 [95% CI 1.01–2.64], p = 0.044). The incidence of CMV disease in this cohort was low and not influenced by the preventive strategy used. However, patients on CMV prophylaxis were more likely to be free from graft failure.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Garzoni, Christian, Cusini, Alexia


600 Technology > 610 Medicine & health








Annelies Luginbühl

Date Deposited:

21 Mar 2014 10:42

Last Modified:

05 Dec 2022 14:29

Publisher DOI:


Uncontrolled Keywords:

Antiviral prophylaxis, graft loss, indirect effects, preemptive therapy, valganciclovir




Actions (login required)

Edit item Edit item
Provide Feedback