Wiener, Dominique Judith; Welle, Monika Maria; Origgi, Francesco C. (2013). Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat. Veterinary dermatology, 24(5), 543-e130. Blackwell Science 10.1111/vde.12063
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BACKGROUND
Within the context of an increased epidemiological pressure caused by canine distemper virus (CDV) in Switzerland together with a potential re-emergence of endemic pathogens such as orthopoxviruses (OPXV), dual infections are possible among susceptible species.
OBJECTIVE
To describe a case of concurrent CDV and OPXV infection in a cat.
ANIMAL
A 5-year-old, neutered male cat was presented with erythema, crusts and ulcerations around the left eye. High-grade pruritus and a severe conjunctivitis were also present.
METHODS
Formalin-fixed skin biopsy samples were obtained from lesional skin. Histopathology, CDV immunohistochemistry and CDV and OPXV RT-PCR were performed.
RESULTS
Histopathological examination showed severe epidermal necrosis extending to the follicular walls and a dermal infiltration, predominantly eosinophilic. Intranuclear and intracytoplasmic eosinophilic inclusion bodies were visible in the wall of affected hair follicles, with occasional formation of syncytia. The RT-PCR revealed the contextual presence of both CDV and OPXV. Scattered cells stained positive for CDV by immunohistochemistry.
CONCLUSION AND DISCUSSION
Dual infections with CDV and OPXV, although rare, may occur and represent additional differential diagnoses for ulcerative skin lesions in cats.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Research Foci > DermFocus 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI) |
UniBE Contributor: |
Wiener, Dominique Judith, Welle, Monika Maria, Origgi, Francesco |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0959-4493 |
Publisher: |
Blackwell Science |
Language: |
English |
Submitter: |
Susanne Portner |
Date Deposited: |
07 Aug 2014 10:36 |
Last Modified: |
05 Dec 2022 14:29 |
Publisher DOI: |
10.1111/vde.12063 |
PubMed ID: |
23869471 |
BORIS DOI: |
10.7892/boris.44326 |
URI: |
https://boris.unibe.ch/id/eprint/44326 |
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