Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat.

Wiener, Dominique Judith; Welle, Monika Maria; Origgi, Francesco C. (2013). Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat. Veterinary dermatology, 24(5), 543-e130. Blackwell Science 10.1111/vde.12063

[img] Text
vde12063.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

BACKGROUND

Within the context of an increased epidemiological pressure caused by canine distemper virus (CDV) in Switzerland together with a potential re-emergence of endemic pathogens such as orthopoxviruses (OPXV), dual infections are possible among susceptible species.

OBJECTIVE

To describe a case of concurrent CDV and OPXV infection in a cat.

ANIMAL

A 5-year-old, neutered male cat was presented with erythema, crusts and ulcerations around the left eye. High-grade pruritus and a severe conjunctivitis were also present.

METHODS

Formalin-fixed skin biopsy samples were obtained from lesional skin. Histopathology, CDV immunohistochemistry and CDV and OPXV RT-PCR were performed.

RESULTS

Histopathological examination showed severe epidermal necrosis extending to the follicular walls and a dermal infiltration, predominantly eosinophilic. Intranuclear and intracytoplasmic eosinophilic inclusion bodies were visible in the wall of affected hair follicles, with occasional formation of syncytia. The RT-PCR revealed the contextual presence of both CDV and OPXV. Scattered cells stained positive for CDV by immunohistochemistry.

CONCLUSION AND DISCUSSION

Dual infections with CDV and OPXV, although rare, may occur and represent additional differential diagnoses for ulcerative skin lesions in cats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Wiener, Dominique Judith; Welle, Monika Maria and Origgi, Francesco

Subjects:

600 Technology > 630 Agriculture

ISSN:

0959-4493

Publisher:

Blackwell Science

Language:

English

Submitter:

Susanne Portner

Date Deposited:

07 Aug 2014 10:36

Last Modified:

14 Oct 2015 11:17

Publisher DOI:

10.1111/vde.12063

PubMed ID:

23869471

BORIS DOI:

10.7892/boris.44326

URI:

https://boris.unibe.ch/id/eprint/44326

Actions (login required)

Edit item Edit item
Provide Feedback