Prognostic value of the Geneva prediction rule in patients with pulmonary embolism

Bertoletti, Laurent; Le Gal, Grégoire; Aujesky, Drahomir; Sanchez, Olivier; Roy, Pierre-Marie; Verschuren, Franck; Bounameaux, Henri; Perrier, Arnaud; Righini, Marc (2013). Prognostic value of the Geneva prediction rule in patients with pulmonary embolism. Thrombosis research, 132(1), pp. 32-36. Elsevier 10.1016/j.thromres.2013.05.001

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BACKGROUND Assessment of pre-test probability of pulmonary embolism (PE) and prognostic stratification are two widely recommended steps in the management of patients with suspected PE. Some items of the Geneva prediction rule may have a prognostic value. We analyzed whether the initial probability assessed by the Geneva rule was associated with the outcome of patients with PE. METHODS In a post-hoc analysis of a multicenter trial including 1,693 patients with suspected PE, the all-cause death or readmission rates during the 3-month follow-up of patients with confirmed PE were analyzed. PE probability group was prospectively assessed by the revised Geneva score (RGS). Similar analyses were made with the a posteriori-calculated simplified Geneva score (SGS). RESULTS PE was confirmed in 357 patients and 21 (5.9%) died during the 3-month follow-up. The mortality rate differed significantly with the initial RGS group, as with the SGS group. For the RGS, the mortality increased from 0% (95% Confidence Interval: [0-5.4%]) in the low-probability group to 14.3% (95% CI: [6.3-28.2%]) in the high-probability group, and for the SGS, from 0% (95% CI: [0-5.4%] to 17.9% (95% CI: [7.4-36%]). Readmission occurred in 58 out of the 352 patients with complete information on readmission (16.5%). No significant change of readmission rate was found among the RGS or SGS groups. CONCLUSIONS Returning to the initial PE probability evaluation may help clinicians predict 3-month mortality in patients with confirmed PE. (ClinicalTrials.gov: NCT00117169).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Aujesky, Drahomir

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0049-3848

Publisher:

Elsevier

Language:

English

Submitter:

Patricia Rajaonina

Date Deposited:

31 Mar 2014 10:24

Last Modified:

09 Nov 2015 10:55

Publisher DOI:

10.1016/j.thromres.2013.05.001

PubMed ID:

23714176

Uncontrolled Keywords:

CI, CT, MDCTA, OR, Odds Ratio, PE, PESI, Pulmonary Embolism Severity Index, Pulmonary embolism, RGS, Revised Geneva Score, SGS, Simplified Geneva Score, V/Q, clinical prediction rule, computed tomography, confidence intervals, death, multidetector computed tomography angiography, prognosis, pulmonary embolism, readmission, ventilation-perfusion scintigraphy rule computed tomography confidence intervals death multidetector computed tomography angiography prognosis pulmonary embolism readmission ventilation-perfusion scintigraphy

BORIS DOI:

10.7892/boris.44361

URI:

https://boris.unibe.ch/id/eprint/44361

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