Atypical visual processing in posttraumatic stress disorder

Mueller-Pfeiffer, Christoph; Schick, Matthis; Schulte-Vels, Thomas; O'Gorman, Ruth; Michels, Lars; Martin-Soelch, Chantal; Blair, James R.; Rufer, Michael; Schnyder, Ulrich; Zeffiro, Thomas; Hasler, Gregor (2013). Atypical visual processing in posttraumatic stress disorder. NeuroImage: Clinical, 3, pp. 531-538. Elsevier 10.1016/j.nicl.2013.08.009

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BACKGROUND: Many patients with Posttraumatic Stress Disorder (PTSD) feel overwhelmed in situations with high levels of sensory input, as in crowded situations with complex sensory characteristics. These difficulties might be related to subtle sensory processing deficits similar to those that have been found for sounds in electrophysiological studies. METHOD: Visual processing was investigated with functional magnetic resonance imaging in trauma-exposed participants with (N = 18) and without PTSD (N = 21) employing a picture-viewing task. RESULTS: Activity observed in response to visual scenes was lower in PTSD participants 1) in the ventral stream of the visual system, including striate and extrastriate, inferior temporal, and entorhinal cortices, and 2) in dorsal and ventral attention systems (P < 0.05, FWE-corrected). These effects could not be explained by the emotional salience of the pictures. CONCLUSIONS: Visual processing was substantially altered in PTSD in the ventral visual stream, a component of the visual system thought to be responsible for object property processing. Together with previous reports of subtle auditory deficits in PTSD, these findings provide strong support for potentially important sensory processing deficits, whose origins may be related to dysfunctional attention processes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Hasler, Gregor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Daniela Zurkinden

Date Deposited:

09 Apr 2014 15:12

Last Modified:

16 Dec 2014 11:40

Publisher DOI:

10.1016/j.nicl.2013.08.009

PubMed ID:

24371791

BORIS DOI:

10.7892/boris.44472

URI:

https://boris.unibe.ch/id/eprint/44472

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