Toward global prevention of sexually transmitted infections (STIs): The need for STI vaccines.

Gottlieb, Sami L; Low, Nicola; Newman, Lori M; Bolan, Gail; Kamb, Mary; Broutet, Nathalie (2014). Toward global prevention of sexually transmitted infections (STIs): The need for STI vaccines. Vaccine, 32(14), pp. 1527-1535. Elsevier 10.1016/j.vaccine.2013.07.087

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An estimated 499 million curable sexually transmitted infections (STIs; gonorrhea, chlamydia, syphilis, and trichomoniasis) occurred globally in 2008. In addition, well over 500 million people are estimated to have a viral STI such as herpes simplex virus type 2 (HSV-2) or human papillomavirus (HPV) at any point in time. STIs result in a large global burden of sexual, reproductive, and maternal-child health consequences, including genital symptoms, pregnancy complications, cancer, infertility, and enhanced HIV transmission, as well as important psychosocial consequences and financial costs. STI control strategies based primarily on behavioral primary prevention and STI case management have had clear successes, but gains have not been universal. Current STI control is hampered or threatened by several behavioral, biological, and implementation challenges, including a large proportion of asymptomatic infections, lack of feasible diagnostic tests globally, antimicrobial resistance, repeat infections, and barriers to intervention access, availability, and scale-up. Vaccines against HPV and hepatitis B virus offer a new paradigm for STI control. Challenges to existing STI prevention efforts provide important reasons for working toward additional STI vaccines. We summarize the global epidemiology of STIs and STI-associated complications, examine challenges to existing STI prevention efforts, and discuss the need for new STI vaccines for future prevention efforts.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Low, Nicola

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0264-410X

Publisher:

Elsevier

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

30 Apr 2014 12:03

Last Modified:

05 Dec 2022 14:29

Publisher DOI:

10.1016/j.vaccine.2013.07.087

PubMed ID:

24581979

Uncontrolled Keywords:

Prevention and control Sexually transmitted diseases Vaccines

BORIS DOI:

10.7892/boris.44503

URI:

https://boris.unibe.ch/id/eprint/44503

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