The genetic basis of craniofacial and dental abnormalities

Kouskoura, Thaleia; Fragou, Natassa; Alexiou, Maria; John, Nessy; Sommer, Lukas; Graf, Daniel; Katsaros, Christos; Mitsiadis, Thimios A (2011). The genetic basis of craniofacial and dental abnormalities. Schweizerische Monatsschrift für Zahnmedizin, 121(7-8), pp. 636-646. Bern: Schweizerische Zahnärzte-Gesellschaft

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The embryonic head development, including the formation of dental structures, is a complex and delicate process guided by specific genetic programs. Genetic changes and environmental factors can disturb the execution of these programs and result in abnormalities in orofacial and dental structures. Orofacial clefts and hypodontia/ oligodontia are examples of such abnormalities frequently seen in dental clinics. An insight into the mechanisms and genes involved in the formation of orofacial and dental structures has been gradually gained by genetic analysis of families and by the use of experimental vertebrate models such as the mouse and chick models. The development of novel clinical therapies for orofacial and dental pathological conditions depends very much on a detailed knowledge of the molecular and cellular processes that are involved in head formation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Orthodontics

UniBE Contributor:

Kouskoura, Thaleia and Katsaros, Christos

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0256-2855

Publisher:

Schweizerische Zahnärzte-Gesellschaft

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:16

Last Modified:

25 Jan 2017 12:16

PubMed ID:

21861247

BORIS DOI:

10.7892/boris.4451

URI:

https://boris.unibe.ch/id/eprint/4451 (FactScience: 208665)

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