Saliva/pathogen biomarker signatures and periodontal disease progression

Kinney, J S; Morelli, T; Braun, T; Ramseier, C A; Herr, A E; Sugai, J V; Shelburne, C E; Rayburn, L A; Singh, A K; Giannobile, W V (2011). Saliva/pathogen biomarker signatures and periodontal disease progression. Journal of dental research, 90(6), pp. 752-8. Thousand Oaks, Calif.: Sage 10.1177/0022034511399908

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The purpose of this study was to determine the role of saliva-derived biomarkers and periodontal pathogens during periodontal disease progression (PDP). One hundred human participants were recruited into a 12-month investigation. They were seen bi-monthly for saliva and clinical measures and bi-annually for subtraction radiography, serum and plaque biofilm assessments. Saliva and serum were analyzed with protein arrays for 14 pro-inflammatory and bone turnover markers, while qPCR was used for detection of biofilm. A hierarchical clustering algorithm was used to group study participants based on clinical, microbiological, salivary/serum biomarkers, and PDP. Eighty-three individuals completed the six-month monitoring phase, with 39 [corrected] exhibiting PDP, while 44 [corrected] demonstrated stability. Participants assembled into three clusters based on periodontal pathogens, serum and salivary biomarkers. Cluster 1 members displayed high salivary biomarkers and biofilm; 71% [corrected] of these individuals were undergoing PDP. Cluster 2 members displayed low biofilm and biomarker levels; 76% [corrected] of these individuals were stable. Cluster 3 members were not discriminated by PDP status; however, cluster stratification followed groups 1 and 2 based on thresholds of salivary biomarkers and biofilm pathogens. The association of cluster membership to PDP was highly significant (p < 0.0007). [corrected] The use of salivary and biofilm biomarkers offers potential for the identification of PDP or stability (ClinicalTrials.gov number, CT00277745).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Ramseier, Christoph Andreas

ISSN:

0022-0345

Publisher:

Sage

Language:

English

Submitter:

Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:16

Last Modified:

25 Jan 2017 12:16

Publisher DOI:

10.1177/0022034511399908

PubMed ID:

21406610

Web of Science ID:

000290441600011

URI:

https://boris.unibe.ch/id/eprint/4468 (FactScience: 208688)

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