In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites.

Barna, Fabienne; Debache, Karim; Vock, Carsten A.; Küster, Tatiana; Hemphill, Andrew (2013). In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites. Antimicrobial agents and chemotherapy, 57(11), pp. 5747-5754. American Society for Microbiology 10.1128/AAC.02446-12

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Upon the screening of 16 antiproliferative compounds against Toxoplasma gondii and Neospora caninum, two hydrolytically stable ruthenium complexes (compounds 16 and 18) exhibited 50% inhibitory concentrations of 18.7 and 41.1 nM (T. gondii) and 6.7 and 11.3 nM (N. caninum). To achieve parasiticidal activity with compound 16, long-term treatment (22 to 27 days at 80 to 160 nM) was required. Transmission electron microscopy demonstrated the rapid impact on and ultrastructural alterations in both parasites. These preliminary findings suggest that the potential of ruthenium-based compounds should thus be further exploited.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Barna, Fabienne; Debache, Karim; Küster, Tatiana and Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Susanne Portner

Date Deposited:

06 Aug 2014 16:31

Last Modified:

10 Sep 2017 01:34

Publisher DOI:

10.1128/AAC.02446-12

PubMed ID:

23979747

BORIS DOI:

10.7892/boris.44715

URI:

https://boris.unibe.ch/id/eprint/44715

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