A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

Kerr, A R; Warnakulasuriya, S; Mighell, A J; Dietrich, T; Nasser, M; Rimal, J; Jalil, A; Bornstein, M M; Nagao, T; Fortune, F; Hazarey, V H; Reichart, P A; Silverman, S; Johnson, N W (2011). A systematic review of medical interventions for oral submucous fibrosis and future research opportunities. Oral diseases, 17 Suppl 1, pp. 42-57. Malden, Mass.: Wiley 10.1111/j.1601-0825.2011.01791.x

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Oral Diseases (2011) 17 (Suppl. 1), 42-57 Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non-surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low-cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology

UniBE Contributor:

Bornstein, Michael and Reichart, Peter








Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 14:16

Last Modified:

25 Jan 2017 12:16

Publisher DOI:


PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/4475 (FactScience: 208695)

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