Equine pastern vasculitis: a clinical and histopathological study.

Psalla, Dimitra; Rüfenacht, Silvia; Stoffel, Michael Hubert; Chiers, Koen; Gaschen, Véronique; Doherr, Marcus G.; Gerber, Vinzenz; Welle, Monika M. (2013). Equine pastern vasculitis: a clinical and histopathological study. Veterinary journal, 198(2), pp. 524-530. Elsevier 10.1016/j.tvjl.2013.09.001

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Equine pastern vasculitis is clinically challenging and the underlying aetiopathogenesis is unclear. The aims of this retrospective study were to establish histopathological criteria for pastern vasculitis, to look for an underlying cause, to investigate whether the histopathological lesions are associated with a distinct clinical picture, to assess if and how the clinical picture varies, and to determine the treatment response. Skin biopsies and clinical data from 20 horses with a diagnosis of vasculitis of the distal extremities were investigated and histology was compared to biopsies from healthy horses. It was concluded that intramural inflammatory cells, leukocytoclasia with nuclear dust, thickening and oedema of the vessel walls, and microhaemorrhages are highly specific histological findings in equine pastern vasculitis. Based on the feedback from the clinicians, the lesions were mostly seen on the lateral and medial aspects of un-pigmented legs. Lesions in white skin were characterised by exudation and crusts, whereas those in pigmented skin were alopecic and characterised by scaling. The response to treatment was poor and the prognosis guarded. No association was found between any of the histopathological findings and a distinct clinical picture. An underlying cause of equine pastern vasculitis could not be identified. Considering the large number of confounding factors, the causative agents are difficult to identify, but may involve drugs or a hypersensitivity reactions to yet unknown antigens.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Anatomy
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
09 Interdisciplinary Units > Microscopy Imaging Center MIC

UniBE Contributor:

Stoffel, Michael Hubert; Gaschen, Véronique; Doherr, Marcus; Gerber, Vinzenz and Welle, Monika Maria

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Susanne Portner

Date Deposited:

16 Jul 2014 16:35

Last Modified:

22 Jan 2019 13:22

Publisher DOI:

10.1016/j.tvjl.2013.09.001

PubMed ID:

24120451

Uncontrolled Keywords:

Histopathology, Horse, Pastern dermatitis, Treatment, Vasculitis

URI:

https://boris.unibe.ch/id/eprint/44804

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