Cotrimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study

Hasse, Barbara; Walker, A Sarah; Fehr, Jan; Furrer, Hansjakob; Hoffmann, Matthias; Battegay, Manuel; Calmy, Alexandra; Fellay, Jacques; Di Benedetto, Caroline; Weber, Rainer; Ledergerber, Bruno; Swiss HIV Cohort, Study (2014). Cotrimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study. Antimicrobial agents and chemotherapy, 58(4), pp. 2363-2368. American Society for Microbiology 10.1128/AAC.01868-13

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Cotrimoxazole reduces mortality in HIV-infected adults with tuberculosis (TB), and in vitro data suggest potential anti-mycobacterial activity of cotrimoxazole. We aimed to evaluate whether prophylaxis with cotrimoxazole is associated with a decreased risk of incident TB in SHCS participants. We determined the incidence of TB per 1000 person-years from January 1992 to December 2012. Rates were analyzed separately in participants with current or no previous antiretroviral treatment (ART) using Poisson regression adjusted for CD4 cell count, sex, region of origin, injecting drug use, and age. 13,431 cohort participants contributed 107,549 person-years follow-up; 182 patients had incident TB; 132 (73%) before and 50 (27%) after ART initiation. The multivariable incidence rate ratios for cumulative cotrimoxazole exposure per year for persons with no previous and current ART were 0.70 (95% CI 0.55-0.89) and 0.87 (0.74-1.0) respectively. Cotrimoxazole may prevent the development of TB among HIV-positive persons, especially among those with no previous ART.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Furrer, Hansjakob

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

21 Mar 2014 16:54

Last Modified:

04 Jul 2017 14:53

Publisher DOI:

10.1128/AAC.01868-13

PubMed ID:

24514096

BORIS DOI:

10.7892/boris.44818

URI:

https://boris.unibe.ch/id/eprint/44818

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