Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3

Nagel, Angela; Lang, Angelika; Engel, Dorothee; Podstawa, Eva; Hunzelmann, Nicolas; de Pita, Ornella; Borradori, Luca; Uter, Wolfgang; Hertl, Michael (2010). Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3. Clinical immunology, 134(3), pp. 320-330. San Diego, Calif.: Elsevier 10.1016/j.clim.2009.11.006

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Pemphigus vulgaris (PV) is a severe autoimmune bullous skin disease and is primarily associated with IgG against desmoglein 3 (dsg3), a desmosomal adhesion protein. In light of the recent association of autoreactive T helper (Th) 2 cells with active PV, the present study sought to relate the occurrence of Th2-regulated dsg3-specific autoantibody subtypes, i.e. IgE and IgG4, in 93 well-characterized PV patients. Patients with acute onset PV (n=37) showed the highest concentrations of serum IgE and IgG4 autoantibodies, which were significantly lower in PV patients in remission (n=14). Furthermore, there was a strong correlation between dsg3-reactive IgE and IgG4 in acute onset, but not in chronic active (n=42) or remittent patients. Additionally, intercellular IgE deposits were detected in the epidermis of acute onset PV. Thus, dsg3-specific IgE and IgG4 autoantibodies are related to acute onset disease which provides additional support to the concept that PV is a Th2-driven autoimmune disorder.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1521-6616

ISBN:

20015693

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

24 Feb 2015 01:36

Publisher DOI:

10.1016/j.clim.2009.11.006

PubMed ID:

20015693

Web of Science ID:

000274909600009

BORIS DOI:

10.7892/boris.45

URI:

https://boris.unibe.ch/id/eprint/45 (FactScience: 193737)

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