What Ethanol metabolites as biological markers tell us about alcohol use

Wurst, Friedrich Martin; Thon, Natasha; Weinmann, Wolfgang; Yeges, Michel; Preuss, Ulrich (2013). What Ethanol metabolites as biological markers tell us about alcohol use. Wiener medizinische Wochenschrift - Skriptum, Kongressjournal, 164(1-2), pp. 25-33. Springer 10.1007/s10354-013-0254-9

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Alcohol and tobacco related disorders are the two leading and most expensive
causes of illness in central Europe. In addition to self reports and questionnaires, biomarkers are of relevance in diagnosis and therapy of alcohol
use disorders.Traditional biomarkers such as gamma glutamyl transpeptidase or
mean corpuscualr volume are indirect biomarkers and are subject to influence of age, gender and non alcohol related diseases, among others.Direct ethanol
metabolites such as ethyl glucuronide (EtG), ethyl sulphate (EtS) and
phosphatidylethanol (PEth) are direct metabolites of ethanol, that are positive
after intake of ethyl alcohol. They represent useful diagnostic tools for
identifying alcohol use even more accurately than traditional biomarkers. Each of these drinking indicators remains positive in serum and urine for a
characteristic time spectrum after the cessation of ethanol intake-EtG and EtS in
urine up to 7 days, EtG in hair for months after ethanol has left the body.
Applications include clinical routine use, emergency room settings, proof of
abstinence in alcohol rehabilitation programs, driving under influence offenders,
workplace testing, assessment of alcohol intake in the context of liver
transplantation and fetal alcohol syndrome.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Chemistry and Toxicology

UniBE Contributor:

Weinmann, Wolfgang

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1613-3803

Publisher:

Springer

Language:

English

Submitter:

Katrin Renfer

Date Deposited:

07 Jul 2014 18:01

Last Modified:

13 Oct 2017 19:38

Publisher DOI:

10.1007/s10354-013-0254-9

PubMed ID:

24322386

BORIS DOI:

10.7892/boris.45074

URI:

https://boris.unibe.ch/id/eprint/45074

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