Adult Neurogenesis in Drosophila

Fernández Hernández, Ismael; Rhiner, Christa; Moreno, Eduardo (2013). Adult Neurogenesis in Drosophila. Cell reports, 3(6), pp. 1857-1865. Cell Press 10.1016/j.celrep.2013.05.034

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Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain. So far, formation of new neurons has not been detected in adult fly brains and hence has been thought to be absent in Drosophila. Here, we used an improved lineage-labeling method to show that, surprisingly, adult neurogenesis occurs in the medulla cortex of the Drosophila optic lobes. We also find that acute brain damage to this region stimulates adult neurogenesis. Finally, we identify a factor induced by acute damage, which is sufficient to specifically activate the proliferation of a cell type with adult neuroblast characteristics. Our results reveal unexpected plasticity in the adult Drosophila brain and describe a unique model for the genetic analysis of adult neurogenesis, plasticity, and brain regeneration.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Fernandez Hernandez, Ismael; Rhiner, Christa and Moreno, Eduardo

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2211-1247

Publisher:

Cell Press

Language:

English

Submitter:

Eduardo Moreno

Date Deposited:

29 Apr 2014 11:58

Last Modified:

13 Dec 2014 12:02

Publisher DOI:

10.1016/j.celrep.2013.05.034

BORIS DOI:

10.7892/boris.45339

URI:

https://boris.unibe.ch/id/eprint/45339

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