Levayer, Romain; Moreno, Eduardo (2013). Mechanisms of cell competition: Themes and variations. Journal of cell biology, 200(6), pp. 689-698. Rockefeller Institute Press 10.1083/jcb.201301051
|
Text
Levayer and Moreno 2013.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-Share Alike (CC-BY-NC-SA). Download (2MB) | Preview |
Cell competition is the short-range elimination of slow-dividing cells through apoptosis when confronted with a faster growing population. It is based on the comparison of relative cell fitness between neighboring cells and is a striking example of tissue adaptability that could play a central role in developmental error correction and cancer progression in both Drosophila melanogaster and mammals. Cell competition has led to the discovery of multiple pathways that affect cell fitness and drive cell elimination. The diversity of these pathways could reflect unrelated phenomena, yet recent evidence suggests some common wiring and the existence of a bona fide fitness comparison pathway.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology |
UniBE Contributor: |
Levayer, Romain, Moreno, Eduardo |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science |
ISSN: |
0021-9525 |
Publisher: |
Rockefeller Institute Press |
Language: |
English |
Submitter: |
Eduardo Moreno |
Date Deposited: |
29 Apr 2014 12:05 |
Last Modified: |
05 Dec 2022 14:30 |
Publisher DOI: |
10.1083/jcb.201301051 |
BORIS DOI: |
10.7892/boris.45341 |
URI: |
https://boris.unibe.ch/id/eprint/45341 |
Actions (login required)
 |
Edit item |