Mechanisms of cell competition: Themes and variations

Levayer, Romain; Moreno, Eduardo (2013). Mechanisms of cell competition: Themes and variations. Journal of cell biology, 200(6), pp. 689-698. Rockefeller Institute Press 10.1083/jcb.201301051

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Cell competition is the short-range elimination of slow-dividing cells through apoptosis when confronted with a faster growing population. It is based on the comparison of relative cell fitness between neighboring cells and is a striking example of tissue adaptability that could play a central role in developmental error correction and cancer progression in both Drosophila melanogaster and mammals. Cell competition has led to the discovery of multiple pathways that affect cell fitness and drive cell elimination. The diversity of these pathways could reflect unrelated phenomena, yet recent evidence suggests some common wiring and the existence of a bona fide fitness comparison pathway.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Levayer, Romain and Moreno, Eduardo

Subjects:

500 Science > 570 Life sciences; biology
500 Science

ISSN:

0021-9525

Publisher:

Rockefeller Institute Press

Language:

English

Submitter:

Eduardo Moreno

Date Deposited:

29 Apr 2014 12:05

Last Modified:

08 Dec 2014 17:53

Publisher DOI:

10.1083/jcb.201301051

BORIS DOI:

10.7892/boris.45341

URI:

https://boris.unibe.ch/id/eprint/45341

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