The role of zinc dynamics in growth hormone secretion

Miletta, Maria Consolata; Schöni, Martin Heinrich; Kernland Lang, Kristin Helene; Mullis, Primus-Eugen; Petkovic, Vibor (2013). The role of zinc dynamics in growth hormone secretion. Hormone research in paediatrics, 80(6), pp. 381-389. Karger 10.1159/000355408

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Human growth hormone (GH) causes a variety of physiological and metabolic effects in humans and plays a pivotal role in postnatal growth. In somatotroph cells of the anterior pituitary, GH is stored in concentrated forms in secretory granules to be rapidly released upon GH-releasing hormone stimulation. During the process of secretory granule biogenesis, self-association of GH occurs in the compartments of the early secretory pathway (endoplasmic reticulum and Golgi complex). Since this process is greatly facilitated by the presence of zinc ions, it is of importance to understand the potential role of zinc transporters that participate in the fine-tuning of zinc homeostasis and dynamics, particularly in the early secretory pathway. Thus, the role of zinc transporters in supplying the secretory pathway with the sufficient amount of zinc required for the biogenesis of GH-containing secretory granules is essential for normal secretion. This report, illustrated by a clinical case report on transient neonatal zinc deficiency, focuses on the role of zinc in GH storage in the secretory granules and highlights the role of specific zinc transporters in the early secretory pathway.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endokrinologie / Diabetologie / Metabolik (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)

UniBE Contributor:

Miletta, Maria Consolata; Schöni, Martin Heinrich; Kernland Lang, Kristin Helene; Mullis, Primus-Eugen and Petkovic, Vibor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1663-2818

Publisher:

Karger

Language:

English

Submitter:

Monika Schenk

Date Deposited:

13 Jun 2014 10:06

Last Modified:

19 Oct 2015 11:33

Publisher DOI:

10.1159/000355408

PubMed ID:

24296719

Uncontrolled Keywords:

Growth hormone, Secretory pathway, Zinc, Zinc deficiency, Growth impairment

BORIS DOI:

10.7892/boris.45528

URI:

https://boris.unibe.ch/id/eprint/45528

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