Plakins, a Versatile Family of Cytolinkers: Roles in Skin Integrity and in Human Diseases

Bouameur, Jamal-Eddine; Favre, Bertrand; Borradori, Luca (2014). Plakins, a Versatile Family of Cytolinkers: Roles in Skin Integrity and in Human Diseases. Journal of Investigative Dermatology, 134(4), pp. 885-894. Nature Publishing 10.1038/jid.2013.498

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The plakin family consists of giant proteins involved in the cross-linking and organization of the cytoskeleton and adhesion complexes. They further modulate several fundamental biological processes, such as cell adhesion, migration, and polarization or signaling pathways. Inherited and acquired defects of plakins in humans and in animal models potentially lead to dramatic manifestations in the skin, striated muscles, and/or nervous system. These observations unequivocally demonstrate the key role of plakins in the maintenance of tissue integrity. Here we review the characteristics of the mammalian plakin members BPAG1 (bullous pemphigoid antigen 1), desmoplakin, plectin, envoplakin, epiplakin, MACF1 (microtubule-actin cross-linking factor 1), and periplakin, highlighting their role in skin homeostasis and diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Bouameur, Jamal-Eddine; Favre, Bertrand and Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-202X

Publisher:

Nature Publishing

Language:

English

Submitter:

Monika Schenk

Date Deposited:

01 Sep 2014 17:21

Last Modified:

19 Oct 2015 11:30

Publisher DOI:

10.1038/jid.2013.498

PubMed ID:

24352042

BORIS DOI:

10.7892/boris.45562

URI:

https://boris.unibe.ch/id/eprint/45562

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