Cardiac phenotype of Duchenne Muscular Dystrophy: Insights from cellular studies

Shirokova, Natalia; Niggli, Ernst (2013). Cardiac phenotype of Duchenne Muscular Dystrophy: Insights from cellular studies. Journal of molecular and cellular cardiology, 58, pp. 217-224. Elsevier 10.1016/j.yjmcc.2012.12.009

[img]
Preview
Text
JMCC7037R1.pdf - Accepted Version
Available under License Publisher holds Copyright.
This is the author's version of a work that was accepted for publication in Journal of Molecular and Cellular Cardiology. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published see http://dx.doi.org/10.1016/j.yjmcc.2012.12.009.

Download (4MB) | Preview

Dilated cardiomyopathy is a serious and almost inevitable complication of Duchenne Muscular Dystrophy, a devastating and fatal disease of skeletal muscle resulting from the lack of functional dystrophin, a protein linking the cytoskeleton to the extracellular matrix. Ultimately, it leads to congestive heart failure and arrhythmias resulting from both cardiac muscle fibrosis and impaired function of the remaining cardiomyocytes. Here we summarize findings obtained in several laboratories, focusing on cellular mechanisms that result in degradation of cardiac functions in dystrophy. This article is part of a Special Issue entitled "Calcium Signaling in Heart".

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology
09 Interdisciplinary Units > Microscopy Imaging Center (MIC)

UniBE Contributor:

Niggli, Ernst

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-2828

Publisher:

Elsevier

Language:

English

Submitter:

Ernst Niggli

Date Deposited:

02 Jun 2014 15:26

Last Modified:

05 Feb 2019 10:20

Publisher DOI:

10.1016/j.yjmcc.2012.12.009

BORIS DOI:

10.7892/boris.45838

URI:

https://boris.unibe.ch/id/eprint/45838

Actions (login required)

Edit item Edit item
Provide Feedback