Persistent infections after natural transmission of bovine viral diarrhoea virus from cattle to goats and among goats

Bachofen, Claudia; Vogt, Hans-Rudolf; Stalder, Hanspeter; Mathys, Tanja; Zanoni, Reto Giacomo; Hilbe, Monika; Schweizer, Matthias; Peterhans, Ernst (2013). Persistent infections after natural transmission of bovine viral diarrhoea virus from cattle to goats and among goats. Veterinary research, 44, p. 32. Editions scientifiques Elsevier 10.1186/1297-9716-44-32

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Bovine viral diarrhoea virus (BVDV) is an economically important pathogen of cattle worldwide. Infection of a pregnant animal may lead to persistent infection of the foetus and birth of a persistently infected (PI) calf that sheds the virus throughout its life. However, BVD viruses are not strictly species specific. BVDV has been isolated from many domesticated and wild ruminants. This is of practical importance as virus reservoirs in non-bovine hosts may hamper BVDV control in cattle. A goat given as a social companion to a BVDV PI calf gave birth to a PI goat kid. In order to test if goat to goat infections were possible, seronegative pregnant goats were exposed to the PI goat. In parallel, seronegative pregnant goats were kept together with the PI calf. Only the goat to goat transmission resulted in the birth of a next generation of BVDV PI kids whereas all goats kept together with the PI calf aborted. To our knowledge, this is the first report which shows that a PI goat cannot only transmit BVD virus to other goats but that such transmission may indeed lead to the birth of a second generation of PI goats. Genetic analyses indicated that establishment in the new host species may be associated with step-wise adaptations in the viral genome. Thus, goats have the potential to be a reservoir for BVDV. However, the PI goats showed growth retardation and anaemia and their survival under natural conditions remains questionable.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Bachofen, Claudia; Vogt, Hans-Rudolf; Stalder, Hanspeter; Mathys, Tanja; Zanoni, Reto Giacomo; Schweizer, Matthias and Peterhans, Ernst

Subjects:

600 Technology > 630 Agriculture

ISSN:

0928-4249

Publisher:

Editions scientifiques Elsevier

Language:

English

Submitter:

Susanne Portner

Date Deposited:

25 Jul 2014 16:45

Last Modified:

10 Feb 2015 09:13

Publisher DOI:

10.1186/1297-9716-44-32

PubMed ID:

23675947

BORIS DOI:

10.7892/boris.45846

URI:

https://boris.unibe.ch/id/eprint/45846

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