Bullous pemphigoid: therapeutic algrorithm and practical management

Daniel, Benjamin S.; Murrell, Dedee F.; Borradori, Luca (2013). Bullous pemphigoid: therapeutic algrorithm and practical management. Expert Opinion on Orphan Drugs, 1(5), pp. 405-412. Informa 10.1517/21678707.2013.794693

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Introduction: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucosae. BP typically affects the elderly and manifests with severe itch, localised or generalised eczematous, urticated and/or bullous lesions. Its morbidity and impact on the quality of life are important. The disease is significantly associated with neurological disorders, such as stroke, Parkinson disease, major cognitive impairment and multiple sclerosis. Diagnosis of BP critically relies on immunopathologic examinations, particularly direct immunofluorescence microscopy studies. Areas covered: This paper looks at the evidence of therapies commonly used in bullous pemphigoid. Expert opinion: Treatment of BP has been a challenge, given the relative rarity of the disease, lack of good quality randomised controlled trials, the presence of co-morbidities in the affected elderly population and the high mortality rate. Recent controlled studies have indicated that potent topical corticosteroids constitute a more effective therapy for BP when compared to oral corticosteroids in terms of control of the disease, side effect profile and overall survival. Other therapies have been employed with varying success, but are not validated yet. Improved knowledge of the pathophysiology of BP will hopefully allow the development of new immunomodulatory treatments for this debilitating disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2167-8707

Publisher:

Informa

Language:

English

Submitter:

Monika Schenk

Date Deposited:

16 Jun 2014 10:40

Last Modified:

14 Sep 2017 04:11

Publisher DOI:

10.1517/21678707.2013.794693

Uncontrolled Keywords:

autoimmune bullous disease, bullous pemphigoid, management, therapy

BORIS DOI:

10.7892/boris.45899

URI:

https://boris.unibe.ch/id/eprint/45899

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