Imported human rabies in Switzerland, 2012: a diagnostic conundrum

Deubelbeiss, Andrea; Trachsel, Ch.; Bachli, E. B.; Kuffer, A.; Budka, H.; Eniseyskiy, P.; Zimmermann, H.; Wallace, R. M.; Farley, S.; Zanoni, Reto Giacomo (2013). Imported human rabies in Switzerland, 2012: a diagnostic conundrum. Journal of clinical virology, 57(2), pp. 178-181. Elsevier 10.1016/j.jcv.2013.02.001

[img] Text
1-s2.0-S1386653213000413-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (537kB) | Request a copy

Human rabies is rare in Western Europe. It is not easily recognized in the absence of a history of exposure. We describe the clinical course, diagnosis and follow-up of an imported human rabies case in Switzerland. The patient, a U.S. citizen, presented at an outpatient clinic in Iraq with pain in his right shoulder on July 5, 2012. On July 8 he was transferred to a hospital in the United Arab Emirates, where he exhibited progressive encephalitis with coma. On July 29, he was transferred to a hospital in Switzerland, where he died on July 31, 2012. The autopsy showed severe encephalitis. Rabies was diagnosed by the rapid fluorescent focus inhibition test (RFFIT) and confirmed by fluorescence antibody testing (FAT) in brain smears and immunohistochemistry on paraffin-embedded brain sections. The viral strain was characterized by RT-PCR followed by sequencing and phylogenetic analysis as an American bat rabies strain associated with Tadarida brasiliensis. Close contacts and exposed health care workers received postexposure prophylaxis (PEP).

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Deubelbeiss, Andrea and Zanoni, Reto Giacomo

Subjects:

600 Technology > 630 Agriculture

ISSN:

1386-6532

Publisher:

Elsevier

Language:

English

Submitter:

Susanne Portner

Date Deposited:

22 Aug 2014 13:48

Last Modified:

14 Oct 2015 11:33

Publisher DOI:

10.1016/j.jcv.2013.02.001

PubMed ID:

23485347

Uncontrolled Keywords:

Rabies, Human, Clinical record, Diagnosis, Molecular Epidemiology

BORIS DOI:

10.7892/boris.45941

URI:

https://boris.unibe.ch/id/eprint/45941

Actions (login required)

Edit item Edit item
Provide Feedback