Protein deficiency and the growing rat lung. I. Nutritional findings and related lung volumes

Kalenga, Masendu; Tschanz, Stefan A.; Burri, Peter H. (1995). Protein deficiency and the growing rat lung. I. Nutritional findings and related lung volumes. Pediatric research, 37(6), pp. 783-788. Nature Publishing Group 10.1203/00006450-199506000-00018

[img] Text
pr1995123a.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

We investigated the consequences of early malnutrition on milk production by dams and on body weight and structural lung growth of young rats using two models of protein restriction. Dams of the early restriction group were fed an 8% casein diet starting at parturition. Those of the delayed restriction group received a 12% casein diet from lactation d 8-14 and thereafter the 8% diet. After weaning, early restriction and delayed restriction group rats were maintained on low protein until d 49, then refed the control diet (18% casein) up to d 126. Milk was analyzed on d 12. Animals were killed at d 21, 49, and 126 for lung fixation in situ. In this report, we show that protein restriction lowered milk yield to 38% of normal. Milk lipid per gram of dry weight tended to be increased, whereas lactose and protein were significantly decreased. Pups from protein-restricted dams grew less and had lower lung volumes, effects being more serious at d 49. However, specific lung volumes (in milliliters per 100 g body weight) were constantly increased. This means that lung was either less affected than body mass or overdistended due to less connective tissue. After refeeding, both groups showed a remarkable catch-up in growth with restoration of the normal allometric relationship between lung volume and body weight. Thus, even after an early onset of protein restriction to total body, the lung is still capable to substantially recover from growth retardation.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Tschanz, Stefan A. and Burri, Peter Hermann


600 Technology > 610 Medicine & health




Nature Publishing Group




Stefan Andreas Tschanz

Date Deposited:

18 Aug 2014 17:16

Last Modified:

10 Dec 2014 11:28

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback