Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging

Ruder, Thomas D.; Ebert, Lars C.; Khattab, Ahmed A.; Rieben, Robert; Thali, Michael J.; Kamat, Pranitha (2013). Edema is a sign of early acute myocardial infarction on post-mortem magnetic resonance imaging. Forensic science, medicine and pathology, 9(4), pp. 501-505. Springer 10.1007/s12024-013-9459-x

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The aim of this study was to investigate if acute myocardial infarction can be detected by post-mortem cardiac magnetic resonance (PMMR) at an earlier stage than by traditional autopsy, i.e., within less than 4 h after onset of ischemia; and if so, to determine the characteristics of PMMR findings in early acute infarcts. Twenty-one ex vivo porcine hearts with acute myocardial infarction underwent T2-weighted cardiac PMMR imaging within 3 h of onset of iatrogenic ischemia. PMMR imaging findings were compared to macroscopic findings. Myocardial edema induced by ischemia and reperfusion was visible on PMMR in all cases. Typical findings of early acute ischemic injury on PMMR consist of a central zone of intermediate signal intensity bordered by a rim of increased signal intensity. Myocardial edema can be detected on cardiac PMMR within the first 3 h after the onset of ischemia in porcine hearts. The size of myocardial edema reflects the area of ischemic injury in early acute (per-acute) myocardial infarction. This study provides evidence that cardiac PMMR is able to detect acute myocardial infarcts at an earlier stage than traditional autopsy and routine histology.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe

UniBE Contributor:

Ruder, Thomas, Ebert, Lars Christian, Khattab, Ahmed Aziz, Rieben, Robert, Jayadev Kamat, Pranitha


600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology








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Date Deposited:

24 Mar 2014 11:14

Last Modified:

19 Apr 2023 09:23

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