Low single dose gabapentin does not affect prefrontal and occipital gamma-aminobutyric acid concentrations

Preuss, Nora; van der Veen, Jan Willem; Carlson, Paul J.; Shen, Jun; Hasler, Gregor (2013). Low single dose gabapentin does not affect prefrontal and occipital gamma-aminobutyric acid concentrations. European neuropsychopharmacology, 23(12), pp. 1708-1713. Elsevier 10.1016/j.euroneuro.2013.08.006

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The γ-aminobutyric acid (GABA) system has been proposed as a target for novel antidepressant and anxiolytic treatments. Emerging evidence suggests that gabapentin (GBP), an anticonvulsant drug that significantly increases brain GABA levels, is effective in the treatment of anxiety disorders. The current study was designed to measure prefrontal and occipital GABA levels in medication-free healthy subjects after taking 0 mg, 150 mg and 300 mg GBP. Subjects were scanned on a 3T scanner using a transmit-receive head coil that provided a relatively homogenous radiofrequency field to obtain spectroscopy measurement in the medial prefrontal (MPFC) and occipital cortex (OCC). There was no dose-dependent effect of GBP on GABA levels in the OCC or MPFC. There was also no effect on Glx, choline or N-acetyl-aspartate concentrations. The previously reported finding of increased GABA levels after GBP treatment is not evident for healthy subjects at the dose of 150 and 300 mg. As a result, if subjects are scanned on a 3T scanner, low dose GPB is not useful as an experimental challenge agent on the GABA system.

Item Type:

Journal Article (Original Article)

Division/Institute:

07 Faculty of Human Sciences > Institute of Psychology > Cognitive Psychology, Perception and Methodology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Preuss, Nora and Hasler, Gregor

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

0924-977X

Publisher:

Elsevier

Language:

English

Submitter:

Daniela Zurkinden

Date Deposited:

21 Mar 2014 14:13

Last Modified:

21 Mar 2014 14:13

Publisher DOI:

10.1016/j.euroneuro.2013.08.006

PubMed ID:

24071367

URI:

https://boris.unibe.ch/id/eprint/46058

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