Novel biomarkers for the prediction of metastasis in colorectal cancer

Zlobec, Inti (2013). Novel biomarkers for the prediction of metastasis in colorectal cancer. Expert Opinion on Medical Diagnostics, 7(2), pp. 137-146. Informa Healthcare 10.1517/17530059.2013.753054

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INTRODUCTION In patients with metastatic colorectal cancers, multimodal management and the use of biological agents such as monoclonal antibodies have had major positive effects on survival. The ability to predict which patients may be at 'high risk' of distant metastasis could have major implications on patient management. Histomorphological, immunohistochemical or molecular biomarkers are currently being investigated in order to test their potential value as predictors of metastasis. AREAS COVERED Here, the author reviews the clinical and functional data supporting the investigation of three novel promising biomarkers for the prediction of metastasis in patients with colorectal cancer: tumor budding, Raf1 kinase inhibitor protein (RKIP) and metastasis-associated in colon cancer-1 (MACC1). EXPERT OPINION The lifespan of most potential biomarkers is short as evidenced by the rare cases that have successfully made their way into daily practice such as KRAS or microsatellite instability (MSI) status. Although the three biomarkers reviewed herein have the potential to become important predictive biomarkers of metastasis, they have similar hurdles to overcome before they can be implemented into clinical management: standardization and validation in prospective patient cohorts.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zlobec, Inti


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health




Informa Healthcare




Andrea Arnold

Date Deposited:

03 Apr 2014 15:46

Last Modified:

03 Apr 2014 15:46

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

biomarkers, colorectal cancer, MACC1, metastasis, RKIP, tumor budding


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