Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve

Roumy, Aurélien; de Leval, Laurence; Niclauss, Lars; Schäfer, Stephan; Kurtin, Paul; Dogan, Ahmet; von Segesser, Ludwig K.; Ruchat, Patrick (2013). Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve. The Annals of Thoracic Surgery, 95(5), pp. 1782-1784. Elsevier 10.1016/j.athoracsur.2012.08.085

Full text not available from this repository. (Request a copy)

An unusual case of localized amyloid light-chain (AL) amyloidosis and extramedullary plasmacytoma of the mitral valve is described. The worsening of a mitral regurgitation led to investigations and surgery. The valve presented marked distortion and thickening by type AL amyloid associated with a monotypic CD138+ immunoglobulin lambda plasma cell proliferation. Systemic staging showed a normal bone marrow and no evidence of amyloid deposition in other localizations. The patient's outcome after mitral valve replacement was excellent. To our knowledge, this is the first description of a localized AL amyloidosis as well as of a primary extramedullary plasmacytoma of the mitral valve.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute of Pathology
UniBE Contributor:	Schäfer, Stephan
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health
ISSN:	1552-6259
Publisher:	Elsevier
Language:	English
Submitter:	Andrea Arnold
Date Deposited:	03 Apr 2014 14:35
Last Modified:	05 Dec 2022 14:31
Publisher DOI:	10.1016/j.athoracsur.2012.08.085
PubMed ID:	23608260
URI:	https://boris.unibe.ch/id/eprint/46341