Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve

Roumy, Aurélien; de Leval, Laurence; Niclauss, Lars; Schäfer, Stephan; Kurtin, Paul; Dogan, Ahmet; von Segesser, Ludwig K.; Ruchat, Patrick (2013). Localized amyloid light-chain amyloidosis and extramedullary plasmacytoma of the mitral valve. The Annals of Thoracic Surgery, 95(5), pp. 1782-1784. Elsevier 10.1016/j.athoracsur.2012.08.085

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An unusual case of localized amyloid light-chain (AL) amyloidosis and extramedullary plasmacytoma of the mitral valve is described. The worsening of a mitral regurgitation led to investigations and surgery. The valve presented marked distortion and thickening by type AL amyloid associated with a monotypic CD138+ immunoglobulin lambda plasma cell proliferation. Systemic staging showed a normal bone marrow and no evidence of amyloid deposition in other localizations. The patient's outcome after mitral valve replacement was excellent. To our knowledge, this is the first description of a localized AL amyloidosis as well as of a primary extramedullary plasmacytoma of the mitral valve.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Schäfer, Stephan

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1552-6259

Publisher:

Elsevier

Language:

English

Submitter:

Andrea Arnold

Date Deposited:

03 Apr 2014 14:35

Last Modified:

03 Apr 2014 14:35

Publisher DOI:

10.1016/j.athoracsur.2012.08.085

PubMed ID:

23608260

URI:

https://boris.unibe.ch/id/eprint/46341

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