New copper(II) complexes with isoconazole: Synthesis, structures and biological properties

Dulcevscaia, Galina; Kravtsov, V. C.; Macaev, F. Z.; Duca, G. G.; Stingachi, E. P.; Pogrebnoi, S. I.; Boldescu, V. V.; Clapco, S. F.; Tiurina, J. P.; Deseatnic-Ciloci, A. A.; Lipkowski, J.; Liu, S. X.; Decurtins, Silvio; Baca, S. G. (2013). New copper(II) complexes with isoconazole: Synthesis, structures and biological properties. Polyhedron, 52, pp. 106-114. Elsevier 10.1016/j.poly.2012.10.040

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There is an increasing demand for novel metal-based complexes with biologically relevant molecules in technology and medicine. Three new Cu(II) coordination compounds with antifungal agent isoconazole (L), namely mononuclear complexes CuCl2(L)(2) (1), and Cu(O2CMe)(2)(L)(2)center dot 2H(2)O (2) and coordination polymer Cu(pht)(L)(2)(n) (3) (where H(2)pht - o-phthalic acid) were synthesized and characterized by IR spectroscopy, thermogravimetric analysis and X-ray crystallography. X-ray analysis showed that in all complexes, the isoconazole is coordinated to Cu(II) centres by a N atom of the imidazole fragment. In complex I, the square-planar environment of Cu(II) atoms is completed by two N atoms of isoconazole and two chloride ligands, whereas the Cu(II) atoms are coordinated by two N atoms from two isoconazole ligands and two O atoms from the different carboxylate residues: acetate in 2 and phthalate in 3. The formation of an infinite chain through the bridging phthalate ligand is observed in 3. The biosynthetic ability of micromycetes Aspergillus niger CNMN FD 10 in the presence of the prepared complexes 1-3 as well as the antifungal drug isoconazole were studied. Complexes 2 and 3 accelerate the biosynthesis of enzymes (beta-glucosidase, xylanase and endoglucanase) by this fungus. Moreover, a simplified and improved method for the preparation of isoconazole nitrate was developed.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Dulcevscaia, Galina and Decurtins, Silvio

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0277-5387

Publisher:

Elsevier

Language:

English

Submitter:

Gabriela Claudia Frei

Date Deposited:

25 Jul 2014 16:18

Last Modified:

02 Sep 2015 11:38

Publisher DOI:

10.1016/j.poly.2012.10.040

Uncontrolled Keywords:

Isoconazole, Copper(II) complex, Synthesis, X-ray structure, Biological properties

BORIS DOI:

10.7892/boris.46363

URI:

https://boris.unibe.ch/id/eprint/46363

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