Monte Carlo Dose Calculation on Deforming Anatomy

Peterhans, Matthias; Frei, Daniel; Manser, Peter; Reyes, Mauricio; Fix, Michael K (2011). Monte Carlo Dose Calculation on Deforming Anatomy. Zeitschrift für medizinische Physik, 21(2), pp. 113-23. Amsterdam: Elsevier, Urban & Fischer 10.1016/j.zemedi.2010.11.002

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This article presents the implementation and validation of a dose calculation approach for deforming anatomical objects. Deformation is represented by deformation vector fields leading to deformed voxel grids representing the different deformation scenarios. Particle transport in the resulting deformed voxels is handled through the approximation of voxel surfaces by triangles in the geometry implementation of the Swiss Monte Carlo Plan framework. The focus lies on the validation methodology which uses computational phantoms representing the same physical object through regular and irregular voxel grids. These phantoms are chosen such that the new implementation for a deformed voxel grid can be compared directly with an established dose calculation algorithm for regular grids. Furthermore, separate validation of the aspects voxel geometry and the density changes resulting from deformation is achieved through suitable design of the validation phantom. We show that equivalent results are obtained with the proposed method and that no statistically significant errors are introduced through the implementation for irregular voxel geometries. This enables the use of the presented and validated implementation for further investigations of dose calculation on deforming anatomy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Peterhans, Matthias; Frei, Daniel; Manser, Peter; Reyes Aguirre, Mauricio Antonio and Fix, Michael

ISSN:

0939-3889

Publisher:

Elsevier, Urban & Fischer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:16

Last Modified:

03 Apr 2014 23:30

Publisher DOI:

10.1016/j.zemedi.2010.11.002

PubMed ID:

21247744

Web of Science ID:

000293805800005

URI:

https://boris.unibe.ch/id/eprint/4684 (FactScience: 209253)

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