Synthesis of bone-like micro-porous calcium phosphate/iota-carrageenan composites by gel diffusion

Parvinzadeh Gashti, Mazeyar; Stir, Manuela Elena; Hulliger, Jürg (2013). Synthesis of bone-like micro-porous calcium phosphate/iota-carrageenan composites by gel diffusion. Colloids and Surfaces B: Biointerfaces, 110, pp. 426-433. Elsevier 10.1016/j.colsurfb.2013.04.051

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Brushite and octacalcium phosphate (OCP) crystals are well-known precursors of hydroxylapatite (HAp), the main mineral found in bone. In this report, we present a new method for biomimicking brushite and OCP using single and double diffusion techniques. Brushite and OCP crystals were grown in an iota-carrageenan gel. The aggregates were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and thermal gravimetric analysis (TGA). SEM revealed different morphologies of brushite crystals from highly porous aggregates to plate-shaped forms. OCP crystals grown in iota-carrageenan showed a porous spherical shape different from brushite growth forms. The XRD method demonstrated that the single-diffusion method favors the formation of monoclinic brushite. In contrast, the double diffusion method was found to promote the formation of the triclinic octacalcium phosphate OCP phase. By combining the different parameters for crystal growth in carrageenan, such as ion concentration, gel pH and gel density, it is possible to modify the morphology of composite crystals, change the phase of calcium phosphate and modulate the amount of carrageenan inclusion in crystals. This study suggests that iota-carrageenan is a high-molecular-weight polysaccharide that is potentially applicable for controlling calcium phosphate crystallization.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Parvinzadeh Gashti, Mazeyar, Stir, Manuela Elena, Hulliger, Jürg


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry








Franziska Bornhauser-Rufer

Date Deposited:

04 Apr 2014 23:37

Last Modified:

05 Dec 2022 14:31

Publisher DOI:


PubMed ID:



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