Mineralization of calcium phosphate crystals in starch template inducing a brushite kidney stone biomimetic composite

Parvinzadeh Gashti, Mazeyar; Stir, Manuela; Bourquin, Marc; Hulliger, Jurg (2013). Mineralization of calcium phosphate crystals in starch template inducing a brushite kidney stone biomimetic composite. Crystal growth & design, 13(5), pp. 2166-2173. American Chemical Society 10.1021/cg4002434

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Dicalcium phosphate dihydrate (brushite) and octacalcium phosphate (OCP) crystals are precursors of hydroxyapatite (HAp) for tooth enamel, dentine, and bones formation in living organisms. Here, we introduce a new method for biomimicking brushite and OCP in starch using single and double diffusion techniques. Brushite and OCP crystals were grown by precipitation in starch after gelation. The obtained materials were analyzed by infrared spectroscopy (IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), and confocal laser scanning microscopy (CLSM). IR spectra demonstrate starch inclusion by peak shifts in the 2900–3500 cm–1 region. SEM showed two different morphologies: plate-shaped and needle-like crystals. Calcium phosphate/starch aggregates bear strong resemblance to prismatic brushite kidney stones. This may open up a clue to understand the mechanism of kidney stone formation.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Parvinzadeh Gashti, Mazeyar; Stir, Manuela Elena and Hulliger, Jürg

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1528-7483

Publisher:

American Chemical Society

Language:

English

Submitter:

Franziska Bornhauser-Rufer

Date Deposited:

04 Apr 2014 23:20

Last Modified:

24 Aug 2015 14:23

Publisher DOI:

10.1021/cg4002434

BORIS DOI:

10.7892/boris.46848

URI:

https://boris.unibe.ch/id/eprint/46848

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