Repeatability analysis of global and local metrics of brain structural networks

Andreotti, Jennifer; Jann, Kay; Melie-Garcìa, Lester; Giezendanner, Stéphanie; Dierks, Thomas; Federspiel, Andrea (2014). Repeatability analysis of global and local metrics of brain structural networks. Brain connectivity, 4(3), pp. 203-220. Mary Ann Liebert 10.1089/brain.2013.0202

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This is a copy of an article published in the Brain connectivity [©2014 copyright Mary Ann Liebert, Inc.]; Brain connectivity is available online at: http://online.liebertpub.com.

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Computational network analysis provides new methods to analyze the human connectome. Brain structural networks can be characterized by global and local metrics that recently gave promising insights for diagnosis and further understanding of neurological, psychiatric and neurodegenerative disorders. In order to ensure the validity of results in clinical settings the precision and repeatability of the networks and the associated metrics must be evaluated. In the present study, nineteen healthy subjects underwent two consecutive measurements enabling us to test reproducibility of the brain network and its global and local metrics. As it is known that the network topology depends on the network density, the effects of setting a common density threshold for all networks were also assessed. Results showed good to excellent repeatability for global metrics, while for local metrics it was more variable and some metrics were found to have locally poor repeatability. Moreover, between subjects differences were slightly inflated when the density was not fixed. At the global level, these findings confirm previous results on the validity of global network metrics as clinical biomarkers. However, the new results in our work indicate that the remaining variability at the local level as well as the effect of methodological characteristics on the network topology should be considered in the analysis of brain structural networks and especially in networks comparisons.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine

UniBE Contributor:

Andreotti, Jennifer; Jann, Kay; Melie-Garcìa, Lester; Giezendanner, Stéphanie; Dierks, Thomas and Federspiel, Andrea

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2158-0014

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Jennifer Andreotti

Date Deposited:

20 Aug 2014 10:56

Last Modified:

07 Apr 2015 02:30

Publisher DOI:

10.1089/brain.2013.0202

PubMed ID:

24575822

BORIS DOI:

10.7892/boris.46984

URI:

https://boris.unibe.ch/id/eprint/46984

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