%PDF-1.3
1 0 obj
<<
/Kids [ 3 0 R 4 0 R 5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R ]
/Type /Pages
/Count 9
>>
endobj
2 0 obj
<<
/Producer (PyPDF2)
>>
endobj
3 0 obj
<<
/Contents 16 0 R
/Parent 1 0 R
/Resources <<
/Properties <<
/MC1 17 0 R
/MC2 19 0 R
>>
/ColorSpace <<
/Cs6 21 0 R
/DefaultCMYK 23 0 R
/Cs8 23 0 R
>>
/XObject <<
/Fm1 25 0 R
/F0 31 0 R
/F1 46 0 R
/Xi2 69 0 R
/Xi3 73 0 R
/Xi0 74 0 R
/Xi1 76 0 R
>>
/Font <<
/F10 77 0 R
/F2 80 0 R
/F3 81 0 R
/F1 86 0 R
/F6 87 0 R
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 <<
/FirstChar 46
/Widths [ 250 500 0 593 593 593 593 593 0 0 0 0 0 0 0 0 0 0 0 718 625 614 729 552 510 718 0 302 0 0 510 0 0 0 0 0 614 541 562 0 666 1031 0 0 0 0 0 0 0 0 0 552 625 458 625 552 385 625 625 281 0 0 281 927 625 614 625 0 385 437 385 0 552 895 0 552 ]
/Encoding 92 0 R
/Type /Font
/BaseFont /DANPKG+AdvOTfb668818.B
/LastChar 121
/Subtype /Type1
/FontDescriptor 93 0 R
/ToUnicode 95 0 R
>>
/F4 96 0 R
/F5 101 0 R
/F2d5f83fe6-cbb4-41f2-b353-2eb7a96f5508 <<
/FirstChar 80
/Widths [ 572 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 541 0 0 614 552 0 614 0 270 0 0 0 895 593 604 0 0 385 437 0 604 ]
/Encoding 106 0 R
/Type /Font
/BaseFont /DANPKH+AdvOT6374a7c9.BI
/LastChar 117
/Subtype /Type1
/FontDescriptor 107 0 R
/ToUnicode 109 0 R
>>
/F9 110 0 R
/F8 115 0 R
/F7 120 0 R
>>
/ProcSet [ /Text /ImageC /ImageB /PDF /ImageI ]
/ExtGState <<
/GS1 28 0 R
>>
>>
/Trans <<
>>
/Rotate 0
/MediaBox [ 0 0 595.276 779.528 ]
/Annots [ 125 0 R 126 0 R 127 0 R ]
/Type /Page
>>
endobj
4 0 obj
<<
/Contents [ 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/Xi4 138 0 R
/F1 140 0 R
/Fm2 163 0 R
/Xi5 169 0 R
>>
/Font <<
/F11 173 0 R
/F12 178 0 R
/F13 183 0 R
/F3 186 0 R
/F1 191 0 R
/F6 196 0 R
/F7 201 0 R
/F8 206 0 R
/F9 211 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 216 0 R
/Type /Page
/Annots [ 219 0 R ]
>>
endobj
5 0 obj
<<
/Contents [ 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/Xi6 138 0 R
/Xi7 169 0 R
/F1 226 0 R
>>
/Font <<
/F1 191 0 R
/F6 196 0 R
/F11 173 0 R
/F13 183 0 R
/F8 206 0 R
/F9 211 0 R
/F7 201 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 249 0 R
/Type /Page
/Annots [ 250 0 R ]
>>
endobj
6 0 obj
<<
/Contents [ 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/F1 257 0 R
/Fm3 280 0 R
/Xi8 138 0 R
/Xi9 169 0 R
>>
/Font <<
/F11 173 0 R
/F12 178 0 R
/F13 183 0 R
/F3 186 0 R
/F1 191 0 R
/F6 196 0 R
/F7 201 0 R
/F8 206 0 R
/F9 211 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 285 0 R
/Type /Page
/Annots [ 286 0 R ]
>>
endobj
7 0 obj
<<
/Contents [ 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/Fm4 293 0 R
/F1 298 0 R
/Xi10 138 0 R
/Xi11 169 0 R
/Fm5 321 0 R
>>
/Font <<
/F3 186 0 R
/F1 191 0 R
/F7 201 0 R
/F12 178 0 R
/F13 183 0 R
/F8 206 0 R
/F9 211 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 326 0 R
/Type /Page
/Annots [ 327 0 R ]
>>
endobj
8 0 obj
<<
/Contents [ 328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/F1 334 0 R
/Xi12 138 0 R
/Fm6 357 0 R
/Xi13 169 0 R
>>
/Font <<
/F3 186 0 R
/F1 191 0 R
/F6 196 0 R
/F7 201 0 R
/F8 206 0 R
/F9 211 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 362 0 R
/Type /Page
/Annots [ 363 0 R ]
>>
endobj
9 0 obj
<<
/Contents [ 364 0 R 365 0 R 366 0 R 367 0 R 368 0 R 369 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/Xi14 138 0 R
/Xi15 169 0 R
/F1 370 0 R
>>
/Font <<
/F8 206 0 R
/F9 211 0 R
/F6 196 0 R
/F7 201 0 R
/F1 191 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 393 0 R
/Type /Page
/Annots [ 394 0 R ]
>>
endobj
10 0 obj
<<
/Contents [ 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/Xi16 138 0 R
/Xi17 169 0 R
/F1 401 0 R
>>
/Font <<
/F8 206 0 R
/F9 211 0 R
/F7 201 0 R
/F1 191 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 424 0 R
/Type /Page
/Annots [ 425 0 R ]
>>
endobj
11 0 obj
<<
/Contents [ 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R ]
/Parent 1 0 R
/QInserted true
/Resources <<
/ColorSpace <<
/Cs6 134 0 R
/DefaultCMYK 136 0 R
/Cs8 136 0 R
>>
/XObject <<
/F1 432 0 R
/Xi18 138 0 R
/Xi19 169 0 R
>>
/Font <<
/F8 206 0 R
/F9 211 0 R
/F7 201 0 R
/F1 191 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 166 0 R
>>
>>
/MediaBox [ 0 0 595.276 779.528 ]
/Thumb 455 0 R
/Type /Page
/Annots [ 456 0 R ]
>>
endobj
12 0 obj
<<
/D [ 0 /Fit ]
/S /GoTo
>>
endobj
13 0 obj
<<
/Parent 14 0 R
/Title (1)
/A 12 0 R
>>
endobj
14 0 obj
<<
/Count 1
/First 13 0 R
/Last 13 0 R
>>
endobj
15 0 obj
<<
/Type /Catalog
/Pages 1 0 R
/Outlines 14 0 R
>>
endobj
16 0 obj
<<
/Length 18900
>>
stream
q
1 0 0 1 0 0 cm
BT
/F1 12 Tf
14.4 TL
ET
BT
/F2 9 Tf
10.8 TL
ET
q
0 1 -1 0 15 56 cm
BT
1 0 0 1 0 0 Tm
1 0 0 1 0 0 Tm
/F2 9 Tf
10.8 TL
0.2667 0.2667 0.2667 rg
(source\072 ) Tj
0.89 0 0.239 rg
(https\072\057\057doi\056org\05710\0567892\057boris\05647235) Tj
0.2667 0.2667 0.2667 rg
( \174 downloaded\072 29\0563\0562024) Tj
ET
Q
Q
q
q
q
1 0 0 1 0 0 cm
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 Do
Q
q
1 0 0 1 -109 591 cm
/F0 Do
Q
q
/GS1 gs
BT
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
14.4459 0 0 14.4459 172.063 629.2911 Tm
/Cs6 cs
0 0 0 scn
0 Tc
0 Tw
[ (Glycopeptide) -317.6 (dendrimers) -316.4 (as) ] TJ
/F2d5f83fe6-cbb4-41f2-b353-2eb7a96f5508 1 Tf
13.6062 0 TD
[ (Pseudomonas) -321 (aeruginosa) ] TJ
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
-13.6062 -1.3775 TD
[ (biofilm) -318.7 (inhibitors) ] TJ
/F3 1 Tf
8.2493 0 TD
(\201) Tj
/F4 1 Tf
9.9626 0 0 9.9626 172.063 585.4675 Tm
[ (Jean\055Lou) -11.1 (is) -322.4 (Reymond) -9.5 (\054\052) -317.7 (M) -6.3 (yriam) -326.3 (Bergma) -11.5 (nn) -317.1 (and) -328 (T) 64.4 (a) 0 (m) -8 (i) 0 (s) -322.4 (Darbre) ] TJ
7.9702 0 0 7.9702 172.063 561.5432 Tm
[ (Synthet) 13.4 (ic) -348.6 (glycopeptide) -338.8 (dendrimer) 12.8 (s) -351.9 (compose) 11.5 (d) -349.2 (o) 0 (f) -333.7 (a) -348.1 (bran) 14.7 (ched) -343.3 (oligopeptide) -339.7 (tr) 16.7 (ee) -347.7 (structur) 13.6 (e) -348.1 (appended) -336 (with) ] TJ
0 -1.5009 TD
[ (glycos) 12.1 (idic) -753.6 (gr) 14.9 (oups) -752 (at) -752.3 (its) -755 (multiple) -747.3 (N\055term) 11.3 (ini) -752.5 (wer) 12.8 (e) -753.6 (investigate) 10.9 (d) -754.6 (for) -745 (binding) -740.6 (to) -753.4 (the) ] TJ
/F5 1 Tf
41.562 0 TD
[ (Pseudomon) 14.2 (as) ] TJ
-41.562 -1.5009 TD
[ (aerug) 12.6 (inosa) ] TJ
/F4 1 Tf
5.4131 0 TD
[ (lectins) -463.6 (LecB) -469.3 (and) -463.1 (LecA\056) -416.9 (These) -460.8 (lectins) -463.6 (are) -460.3 (partly) -463.7 (res) 12.6 (ponsible) -465.5 (f) 15.5 (o) 0 (r) -468.8 (the) -468.4 (fo) 14.9 (rmation) -463.7 (of) -461.7 (antibiotic) ] TJ
-5.4131 -1.5009 TD
[ (r) 15.5 (esistant) -657.2 (biofilms) -658.6 (in) -661.1 (the) -660.5 (human) -652.8 (pathogenic) -655.3 (bacterium) ] TJ
/F5 1 Tf
27.3713 0 TD
[ (P) 54.1 (\056) -660.1 (aeruginosa) ] TJ
/F4 1 Tf
6.3307 0 TD
[ (\054) -667.3 (which) -651.6 (causes) -661.9 (lethal) -657.9 (airway) ] TJ
-33.702 -1.4938 TD
[ (inf) 15.9 (ections) -579 (in) -575.7 (immune\055co) 13.7 (mprom) 13.2 (ised) -578.6 (and) -576.9 (cystic) -577 (fibro) 16.6 (sis) -581.8 (patients\056) -574.9 (Glycopeptide) -573.4 (dendrimer) 12.8 (s) -579.5 (with) -584.7 (high) ] TJ
0 -1.5009 TD
[ <61026e697479> -732.9 (to) -732 (the) -738.7 (lectins) -733.9 (wer) 12.8 (e) -739.4 (identified) -735 (by) -737.9 (scre) 11.5 (ening) -733 (of) -739.1 (combinato) 16.5 (rial) -743.1 (libr) 17 (aries\056) -738.5 (Sever) 20.9 (al) -745.4 (of) -732 (these) ] TJ
T*
[ (dendrimer) 12.8 (s\054) -592.3 (in) -582.8 (particular) -586 (the) -589.3 (LecB) -590.2 (specific) -585.6 (glycopep) 14.7 (tide) -588.3 (dendrimers) ] TJ
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
33.1543 0 TD
(FD2) Tj
/F4 1 Tf
2.4185 0 TD
(and) Tj
5.5789 0 0 5.5789 474.2361 489.8266 Tm
(D) Tj
7.9702 0 0 7.9702 478.2046 489.8266 Tm
(\055) Tj
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
0.3201 0 TD
(FD2) Tj
/F4 1 Tf
2.4185 0 TD
[ (and) -584.1 (the) -589.3 (LecA) ] TJ
-41.1495 -1.5009 TD
[ (specific) -621.2 (glycopeptide) -623.4 (dendrimer) 12.8 (s) ] TJ
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
16.2037 0 TD
(GalAG2) Tj
/F4 1 Tf
4.211 0 TD
(and) Tj
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
2.3758 0 TD
(GalBG2) Tj
/F4 1 Tf
3.4783 0 TD
[ (\054) -631.7 (also) -628.4 <65026369656e746c79> -625.8 (block) ] TJ
/F5 1 Tf
11.3597 0 TD
[ (P) 54.1 (\056) -631.7 (aerugino) 13.1 (sa) ] TJ
/F4 1 Tf
6.9353 0 TD
(biofilm) Tj
-44.5638 -1.5009 TD
[ (f) 15.5 (ormation) -364.7 (and) -370.7 (induce) -371.3 (biofilm) -363.7 (dispersal) ] TJ
/F5 1 Tf
18.3519 0 TD
[ (in) -354.9 (vitr) 13.4 (o) 13.9 (\056) ] TJ
/F4 1 Tf
3.7842 0 TD
[ (Structur) 19 (e\205activity) -365.7 (relati) 12.6 (onship) -367.4 (and) -370.7 (structur) 20.7 (al) -375.5 (studies) -367.9 (are) ] TJ
-22.1361 -1.5009 TD
[ (r) 15.5 (eviewed\054) -403 (in) -405 (particular) -401 (the) -411.5 (observatio) 16 (n) -413.2 (that) -403.1 (multivalency) -394.6 (is) -407.7 (essential) -408 (to) -404.8 (the) -404.4 (anti\055biofilm) -402.3 <6503> 15.9 (ect) -404.9 (in) -412.1 (these) ] TJ
T*
[ (dendrimer) 12.8 (s\056) ] TJ
/F6 1 Tf
11.9551 0 0 11.9551 303.307 378.8219 Tm
[ (1\056) -499.5 (Introduction) ] TJ
/F7 1 Tf
8.9663 0 0 8.9663 303.307 358.9227 Tm
[ (The) -385.2 (spread) -388.7 (of) -384.2 (antibiotic) -387.5 (resistant) -388.3 (bacteria) -391.1 (is) -386.5 (one) -380.3 (of) -390.6 (the) -386 (most) ] TJ
0 -1.3341 TD
[ (pressing) -554.5 (problems) -551 (in) -554.6 (human) -550.7 (health) -552.7 (today\056) -547.9 (The) -555.9 (ubiquitous) ] TJ
T*
-0.0267 Tc
[ (Gram\055negative) -224.3 (b) 1.5 (acterium) ] TJ
/F8 1 Tf
10.7806 0 TD
-0.0246 Tc
[ (Ps) 3.7 (eu) 4.2 (dom) 7.6 (o) 1.2 (nas) -224 (a) 2.2 (eru) 4.2 (g) 3.4 (ino) 7.5 (s) -2.7 (a) ] TJ
/F7 1 Tf
10.1799 0 TD
-0.0284 Tc
[ (inf) -5.2 (e) 1.7 (ct) -5.2 (s) -230 (i) 1.7 (mm) -6 (une) -4.6 (\055) ] TJ
-20.9604 -1.3341 TD
0 Tc
[ (compromised) -525.5 (and) -526 (cystic) -521.4 (fibrosis) -528.9 (patients) -524.5 (and) -519.6 (causes) -526.6 (lethal) ] TJ
ET
q
1 i
42.52 352.12 m
291.968 352.12 l
291.968 333.014 l
42.52 333.014 l
W
n
q
1 0 0 1 42.52 352.403 cm
0 0 m
755.149 0 l
755.376 -0.113 l
755.376 -0.397 l
755.149 -0.51 l
0 -0.51 l
-0.227 -0.397 l
-0.227 -0.113 l
f*
Q
Q
BT
/F8 1 Tf
6.9738 0 0 6.9738 42.5197 342.9353 Tm
[ (Departmen) -16.2 (t) -320.2 (o) -0.1 (f) -322.7 (Chemistry) -332.5 (and) -324.6 (B) -0.1 (iochemistry\054) -328.5 (Univers) -11.9 (ity) -321.9 (of) -322.7 (Berne) -11.6 (\054) -315.3 (Freistrass) -15 (e) -319 (3) 0 (\054) ] TJ
0 -1.4226 TD
[ (3012) -326.2 (Berne\054) -326.9 (Switzerland) -17.5 (\056) -315.3 (E) -0.1 (\055mail) -11.5 (\072) -323.4 (jean\055louis\056reym) -18.4 (ond\100ioc\056unibe\056ch) ] TJ
/F7 1 Tf
0 -1.4308 TD
[ (\201) -406.6 (P) -0.1 (art) -323.5 (of) -321 (the) -323.6 (m) -0.1 (u) -9.6 (ltivalent) -321.8 <736361026f> -12.1 (l) 0 (ds) -322.9 (in) -321.5 (glycosciences) -327.5 (themed) -333.7 (issue\056) ] TJ
ET
q
1 i
42.52 305.121 m
552.756 305.121 l
552.756 65.197 l
42.52 65.197 l
W
n
q
1 0 0 1 42.52 305.405 cm
0 0 m
755.149 0 l
755.376 -0.113 l
755.376 -0.397 l
755.149 -0.51 l
0 -0.51 l
-0.227 -0.397 l
-0.227 -0.113 l
f*
Q
Q
q
1 i
42.52 297.581 m
289.474 297.581 l
289.474 155.679 l
42.52 155.679 l
W
n
/Fm1 Do
Q
BT
/F9 1 Tf
8.9663 0 0 8.9663 47.3386 143.9433 Tm
[ (Jean\055Louis) -318.6 (Reymond\054) -325.9 (Myriam) -322.7 (Bergmann) -321.7 (and) -317.3 (Tamis) -320.5 (Darbre) ] TJ
/F8 1 Tf
28.1749 16.3827 TD
[ (Jean\055Louis) -555.8 (Reymond) -556.9 (is) -547 (a) -554.9 (Professor) -553.6 (of) -549.4 (Chemistry) -554.9 (and) -554.1 (Chemical) ] TJ
0 -1.3278 TD
[ (Biology) -741 (at) -738.7 (the) -735.9 (University) -742.3 (of) -739.1 (Berne\054) -738 (Switzerland\056) -745 (He) -737.2 (studied) ] TJ
0 -1.3341 TD
[ (chemistry) -452.5 (and) -446.6 (biochemistry) -456.6 (at) -447.8 (the) -445.1 (ETH) -451.1 (Zu) ] TJ
18.21 0.0316 TD
(\250) Tj
0.5185 -0.0316 TD
[ (rich) -448.2 (and) -452.9 (obtained) -450.4 (his) ] TJ
-18.7285 -1.3341 TD
[ (PhD) -376.4 (in) -375.7 (1989) -373.2 (at) -378.3 (the) -369.2 (University) -381.9 (of) -372.4 (Lausanne) -376.6 (in) -375.7 (the) -375.5 (area) -373.6 (of) -372.4 (natural) ] TJ
T*
[ (products) -535 (synthesis\056) -537.3 (He) -528.5 (was) -528.8 (then) -536.4 (a) -529.6 (post\055doctoral) -533.5 (fellow) -531.6 (and) -535.1 (an) ] TJ
T*
[ (Assistant) -471.6 (Professor) -471.5 (at) -466.8 (the) -470.4 (Scripps) -469.4 (Research) -469 (Institute) -471.3 (in) -470.5 (La) -462.2 (Jolla\054) ] TJ
T*
[ (CA\056) -815.5 (In) -818.9 (1997) -815.8 (he) -817.7 (joined) -815.3 (the) -818.1 (Department) -816.3 (of) -815 (Chemistry) -820.5 (and) ] TJ
T*
[ (Biochemistry) -651.2 (at) -637.5 (the) -647.4 (University) -647.5 (of) -644.3 (Berne\056) -643.2 (His) -639.9 (current) -644.9 (research) ] TJ
T*
[ (includes) -730 (the) -723.3 (development) -729.9 (of) -720.2 (peptide) -725.6 (dendrimers) -732.5 (as) -722.6 (artificial) ] TJ
0 -1.3278 TD
[ (proteins) -836.2 (and) -832.3 (glycoproteins\054) -835.2 (drug) -835.4 (delivery) -837.4 (and) -832.3 (antimicrobial) ] TJ
0 -1.3341 TD
[ (agents\054) -325.8 (computer\055aided) -325.5 (drug) -323.2 (design) -321.3 (and) -320.1 (cheminformatics\056) ] TJ
0 -1.1697 TD
[ (Myriam) -412.8 (Bergmann) -418.5 (was) -415 (born) -409.7 (in) -413.6 (Uzwil) -415.7 (\050Switzerland\051) -416.2 (in) -413.6 (1982\056) -419.3 (She) ] TJ
0 -1.3341 TD
[ (studied) -257.7 (biochemistry) -260.6 (at) -258.2 (the) -255.4 (University) -255.5 (of) -258.6 (Zurich) -255.7 (and) -250.6 (did) -258.3 (her) -253 (MSc) -254.3 (on) ] TJ
T*
[ (expression) -260.8 (and) -250.6 (analysis) -260.8 (of) -252.3 (G\055protein) -260.6 (subunits) -260.2 (with) -251.8 (Prof\056) -254.9 (Dr) -255.2 (Andreas) ] TJ
-28.7123 -1.3278 TD
(Plu) Tj
0.8536 0.0253 TD
(\250) Tj
0.5185 -0.0253 TD
[ (ckthun\056) -306.3 (In) -300.4 (2010\054) -305.5 (she) -296.2 (started) -306.3 (her) -303.6 (PhD) -300.6 (under) -296.4 (the) -306 (supervision) -299.8 (of) -302.8 (Prof\056) -299.2 (Dr) -299.4 (Jean\055Louis) -309.2 (Reymond) -297.7 (at) -302.4 (the) -299.7 (University) -306.1 (of) -302.8 (Berne) -299.9 (\050Switzerland\051\056) ] TJ
-1.3721 -1.3341 TD
[ (Her) -292.6 (current) -297.1 (research) -301.3 (interests) -297.6 (are) -299.3 (the) -293.3 (synthesis) -301.5 (and) -294.8 (analysis) -305.1 (of) -296.5 (glycopeptide) -299.1 (dendrimers) -296.2 (as) -299 (Pseudomonas) -298.2 (aeruginosa) -296.8 (biofilm) -300.2 (inhibitors\056) ] TJ
T*
[ (Tamis) -269.9 (Darbre) -274.7 (was) -269.5 (born) -270.6 (in) -274.5 (Brazil) -272.7 (and) -269.5 (received) -270.9 (her) -271.9 (PhD) -269 (from) -268.6 (Rice) -271 (University\054) -276.3 (Houston\054) -273.8 (TX\056) -272.1 (After) -273.9 (her) -265.6 (postdoctoral) -277.1 (work) -271.5 (with) -270.8 (D\056) -271.6 (Arigoni) -267.1 (in) ] TJ
T*
[ (the) -236.4 (ETH\054) -238 (Zu) ] TJ
4.4956 0.0316 TD
(\250) Tj
0.5185 -0.0316 TD
[ (rich\054) -241.4 (Switzerland\054) -239.1 (she) -239.3 (joined) -239.9 (the) -236.4 (Department) -247.3 (of) -233.3 (Chemistry) -245.1 (and) -237.9 (Biochemistry\054) -242.1 (University) -242.8 (of) -233.3 (Berne\054) -238.5 (Switzerland\054) -245.4 (where) -241.8 (in) -236.6 (2003\054) ] TJ
-5.0141 -1.3341 TD
[ (she) -220.3 (completed) -225.1 (her) -221.4 (Habilitation\056) -231.8 (Her) -223 (research) -219.1 (interests) -228 (include) -227.1 (synthesis) -225.6 (of) -220.6 (peptide) -226.1 (dendrimers) -226.6 (and) -218.9 (their) -228 (applications) -225.6 (in) -223.9 (several) -221.4 (fields) -226.2 (such) ] TJ
T*
[ (as) -324.3 (models) -320.2 (for) -319.8 (enzymatic) -324.4 (reactions\054) -324.6 (inhibitors) -327.3 (of) -321.8 (bacterial) -320.2 (biofilms) -328.8 (and) -320.1 (antimicrobials\056) ] TJ
/F3 1 Tf
6.9738 0 0 6.9738 42.5197 480.3022 Tm
0.0001 Tc
[ (Received) -328.3 (10th) -325.1 (Decembe) -13.7 (r) -320.6 (2012) ] TJ
0 -2.2844 TD
[ (DOI\072) -325.2 (10\0561039\057c3) -18.4 (cs35504g) ] TJ
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
0 -3.1461 TD
0 Tc
(www\056rsc\056org\057csr) Tj
ET
0.6 0.6 0.6 scn
1 i
q
1 0 0 1 42.52 682.809 cm
0 0 m
0 11.112 l
0.057 11.282 l
0.113 11.452 l
0.227 11.622 l
0.34 11.735 l
0.51 11.849 l
0.85 11.962 l
509.216 11.962 l
498.274 11.962 l
509.386 11.962 l
509.726 11.849 l
509.896 11.735 l
510.009 11.622 l
510.123 11.452 l
510.179 11.282 l
510.236 11.112 l
510.236 -22.904 l
510.243 -23.527 509.793 -23.858 509.216 -23.924 c
1.02 -23.924 l
11.962 -23.924 l
1.02 -23.924 l
0.85 -23.868 l
0.68 -23.868 l
0.51 -23.754 l
0.34 -23.698 l
0.227 -23.528 l
0.113 -23.414 l
0 -23.074 l
0 -11.962 l
f*
Q
/Cs6 CS
0.6 0.6 0.6 SCN
1 J
1 j
0 w
10 M
[ ] 0 d
q
1 0 0 1 54.482 694.771 cm
0 0 m
486.312 0 l
486.312 -11.962 l
0 -11.962 l
B*
Q
q
1 0 0 1 540.794 694.771 cm
0 0 m
10.942 0 l
11.541 0.009 11.971 -0.421 11.962 -1.02 c
11.962 -11.962 l
0 -11.962 l
B*
Q
q
1 0 0 1 552.756 682.809 cm
0 0 m
0 -11.962 l
-11.962 -11.962 l
-11.962 0 l
B*
Q
q
1 0 0 1 552.756 670.847 cm
0 0 m
0 -10.942 l
0.007 -11.564 -0.443 -11.896 -1.02 -11.962 c
-11.962 -11.962 l
-11.962 0 l
B*
Q
q
1 0 0 1 540.794 658.885 cm
0 0 m
-486.312 0 l
-486.312 11.962 l
0 11.962 l
B*
Q
q
1 0 0 1 54.482 658.885 cm
0 0 m
-10.942 0 l
-11.112 0.057 l
-11.282 0.057 l
-11.452 0.17 l
-11.622 0.227 l
-11.735 0.397 l
-11.849 0.51 l
-11.962 0.85 l
-11.962 11.962 l
0 11.962 l
B*
Q
q
1 0 0 1 42.52 670.847 cm
0 0 m
0 11.962 l
11.962 11.962 l
11.962 0 l
B*
Q
q
1 0 0 1 42.52 682.809 cm
0 0 m
0 10.942 l
-0.009 11.541 0.421 11.971 1.02 11.962 c
11.962 11.962 l
11.962 0 l
B*
Q
BT
/F10 1 Tf
20.9217 0 0 20.9217 42.5197 711.4958 Tm
0 0 0 scn
[ (C) 10.2 (hem) -317.5 (Soc) -321.9 (R) 31.9 (e) 9.9 (v) ] TJ
ET
/EmbeddedDocument /MC1 BDC
/Document /MC2 BDC
/Cs8 cs
0 0 0 1 scn
q
1 0 0 1 463.711 711.809 cm
0 0 m
-0.8 0 -1.455 0.07 -2.117 0.309 c
-3.044 0.645 -3.372 0.986 -3.414 2.826 c
-2.539 1.436 -1.422 0.801 0.108 0.801 c
1.316 0.801 2.66 1.549 2.66 2.924 c
2.66 6.042 -3.358 5.158 -3.358 9.132 c
-3.358 11.31 -1.253 12.18 0.782 12.18 c
1.592 12.18 2.785 11.997 3.655 11.667 c
3.645 10.094 l
3.034 10.792 2.065 11.402 0.736 11.402 c
-0.673 11.402 -1.659 10.565 -1.659 9.492 c
-1.659 6.769 4.292 7.284 4.292 3.47 c
4.292 0.948 2.127 0 0 0 c
f
Q
q
1 0 0 1 478.32 712.432 cm
0 0 m
-1 -0.41 -2.081 -0.637 -3.426 -0.637 c
-4.932 -0.637 -6.408 -0.249 -7.343 0.453 c
-8.676 1.454 -9.475 3.095 -9.475 5.17 c
-9.475 9.078 -7.095 11.584 -3.386 11.584 c
-2.03 11.584 -0.831 11.334 -0.057 11.023 c
-0.057 9.435 l
-0.593 10.042 -1.688 10.805 -3.267 10.805 c
-6.157 10.805 -7.464 8.206 -7.464 5.465 c
-7.464 2.571 -6.143 0.143 -3.133 0.143 c
-2.017 0.143 -0.837 0.662 0 1.505 c
f
Q
q
1 0 0 1 460.09 712.143 cm
0 0 m
-0.528 -0.093 -0.704 -0.107 -1.233 -0.107 c
-1.513 -0.107 -1.917 -0.093 -2.182 0 c
-2.571 0.131 -2.887 0.576 -3.171 1.146 c
-3.496 1.797 -3.842 2.613 -4.146 3.316 c
-4.885 5.019 -5.458 5.297 -6.431 5.297 c
-7.218 5.297 l
-7.218 1.672 l
-7.218 0.963 -7.063 0.156 -6.797 -0.026 c
-9.012 -0.026 l
-9.012 9.846 l
-9.012 10.556 -9.17 11.361 -9.436 11.544 c
-5.556 11.544 l
-3.172 11.544 -1.57 10.501 -1.57 8.555 c
-1.57 6.679 -2.808 5.782 -4.271 5.526 c
-3.468 5.338 -2.916 4.466 -2.43 3.494 c
-1.69 2.013 -1.107 0.23 0 0 c
-3.439 8.518 m
-3.439 10.153 -4.382 10.834 -6.226 10.834 c
-7.218 10.834 l
-7.218 6.014 l
-6.822 6.014 -6.476 6.013 -6.149 6.013 c
-4.57 6.013 -3.439 6.812 -3.439 8.518 c
f
Q
0 0 0 0.6 scn
q
1 0 0 1 482.927 718.108 cm
0 0 m
0.332 -0.087 0.751 -0.122 1.258 -0.122 c
3.092 -0.122 4.21 0.769 4.21 2.376 c
4.21 3.931 3.109 4.682 1.433 4.682 c
0.769 4.682 0.262 4.629 0 4.559 c
h
-1.52 5.643 m
-0.786 5.782 0.175 5.887 1.398 5.887 c
2.9 5.887 4.001 5.538 4.699 4.909 c
5.346 4.35 5.747 3.494 5.747 2.463 c
5.747 1.398 5.433 0.559 4.822 -0.052 c
4.018 -0.908 2.708 -1.345 1.223 -1.345 c
0.769 -1.345 0.349 -1.328 0 -1.24 c
0 -5.974 l
-1.52 -5.974 l
f
Q
q
1 0 0 1 496.937 714.456 cm
0 0 m
0 -0.891 0.018 -1.66 0.07 -2.323 c
-1.293 -2.323 l
-1.38 -0.944 l
-1.415 -0.944 l
-1.799 -1.625 -2.708 -2.516 -4.21 -2.516 c
-5.537 -2.516 -7.127 -1.765 -7.127 1.188 c
-7.127 6.132 l
-5.59 6.132 l
-5.59 1.467 l
-5.59 -0.14 -5.083 -1.24 -3.703 -1.24 c
-2.673 -1.24 -1.957 -0.524 -1.677 0.175 c
-1.589 0.384 -1.537 0.664 -1.537 0.961 c
-1.537 6.132 l
0 6.132 l
f
Q
q
1 0 0 1 500.501 715.521 cm
0 0 m
0 -0.192 0.017 -0.383 0.053 -0.559 c
0.349 -1.625 1.257 -2.357 2.358 -2.357 c
3.983 -2.357 4.925 -1.047 4.925 0.891 c
4.925 2.604 4.053 4.053 2.41 4.053 c
1.362 4.053 0.384 3.319 0.087 2.166 c
0.035 1.974 0 1.764 0 1.52 c
h
-1.537 9.014 m
0 9.014 l
0 3.721 l
0.035 3.721 l
0.576 4.664 1.554 5.258 2.916 5.258 c
5.014 5.258 6.48 3.511 6.48 0.961 c
6.48 -2.079 4.558 -3.581 2.671 -3.581 c
1.45 -3.581 0.489 -3.11 -0.158 -1.991 c
-0.192 -1.991 l
-0.279 -3.389 l
-1.607 -3.389 l
-1.555 -2.812 -1.537 -1.956 -1.537 -1.205 c
f
Q
508.379 712.134 1.537 12.402 re
f
511.978 720.589 1.537 -8.455 re
512.711 722.021 m
512.152 722.021 511.785 722.458 511.785 722.964 c
511.785 723.505 512.169 723.924 512.746 723.924 c
513.305 723.924 513.689 723.505 513.689 722.964 c
513.689 722.458 513.322 722.021 512.729 722.021 c
f
q
1 0 0 1 515.331 713.706 cm
0 0 m
0.472 -0.279 1.276 -0.594 2.044 -0.594 c
3.145 -0.594 3.668 -0.052 3.668 0.664 c
3.668 1.398 3.232 1.782 2.114 2.201 c
0.577 2.76 -0.139 3.599 -0.139 4.594 c
-0.139 5.957 0.978 7.075 2.778 7.075 c
3.633 7.075 4.384 6.848 4.839 6.551 c
4.472 5.45 l
4.14 5.643 3.528 5.94 2.743 5.94 c
1.834 5.94 1.345 5.415 1.345 4.787 c
1.345 4.088 1.834 3.773 2.935 3.337 c
4.384 2.795 5.154 2.062 5.154 0.804 c
5.154 -0.699 3.983 -1.746 2.009 -1.746 c
1.083 -1.746 0.227 -1.502 -0.367 -1.153 c
f
Q
q
1 0 0 1 521.934 724.536 cm
0 0 m
1.537 0 l
1.537 -5.276 l
1.572 -5.276 l
1.816 -4.839 2.201 -4.437 2.672 -4.193 c
3.126 -3.913 3.668 -3.756 4.245 -3.756 c
5.38 -3.756 7.197 -4.455 7.197 -7.372 c
7.197 -12.403 l
5.66 -12.403 l
5.66 -7.529 l
5.66 -6.167 5.153 -5.031 3.703 -5.031 c
2.708 -5.031 1.939 -5.73 1.642 -6.568 c
1.554 -6.778 1.537 -7.005 1.537 -7.302 c
1.537 -12.403 l
0 -12.403 l
f
Q
531.106 720.589 1.537 -8.455 re
531.839 722.021 m
531.28 722.021 530.913 722.458 530.913 722.964 c
530.913 723.505 531.297 723.924 531.874 723.924 c
532.433 723.924 532.817 723.505 532.817 722.964 c
532.817 722.458 532.45 722.021 531.857 722.021 c
f
q
1 0 0 1 534.669 718.3 cm
0 0 m
0 0.891 -0.018 1.59 -0.07 2.288 c
1.293 2.288 l
1.38 0.909 l
1.415 0.909 l
1.834 1.695 2.812 2.481 4.21 2.481 c
5.38 2.481 7.197 1.782 7.197 -1.118 c
7.197 -6.166 l
5.66 -6.166 l
5.66 -1.293 l
5.66 0.07 5.153 1.223 3.703 1.223 c
2.708 1.223 1.922 0.507 1.642 -0.349 c
1.572 -0.542 1.537 -0.821 1.537 -1.065 c
1.537 -6.166 l
0 -6.166 l
f
Q
q
1 0 0 1 549.534 717.269 cm
0 0 m
0 0.245 -0.017 0.472 -0.087 0.681 c
-0.367 1.59 -1.1 2.323 -2.236 2.323 c
-3.704 2.323 -4.751 1.083 -4.751 -0.891 c
-4.751 -2.533 -3.895 -3.93 -2.253 -3.93 c
-1.292 -3.93 -0.436 -3.336 -0.122 -2.341 c
-0.035 -2.096 0 -1.799 0 -1.52 c
h
1.537 -3.895 m
1.537 -5.852 1.136 -7.022 0.332 -7.773 c
-0.506 -8.525 -1.694 -8.787 -2.76 -8.787 c
-3.773 -8.787 -4.891 -8.542 -5.572 -8.088 c
-5.188 -6.9 l
-4.629 -7.266 -3.756 -7.581 -2.707 -7.581 c
-1.135 -7.581 0.018 -6.76 0.018 -4.612 c
0.018 -3.686 l
-0.017 -3.686 l
-0.472 -4.472 -1.397 -5.101 -2.707 -5.101 c
-4.804 -5.101 -6.306 -3.319 -6.306 -0.961 c
-6.306 1.904 -4.437 3.511 -2.48 3.511 c
-1.013 3.511 -0.227 2.76 0.158 2.044 c
0.192 2.044 l
0.244 3.319 l
1.607 3.319 l
1.555 2.725 1.537 2.027 1.537 1.013 c
f
Q
EMC
EMC
BT
/F159e1af58-bbb6-4614-b3ab-cddf9fdd2658 1 Tf
14.4459 0 0 14.4459 49.8898 672.7747 Tm
/Cs6 cs
1 1 1 scn
[ (REVIEW) -297.9 (ARTICLE) ] TJ
ET
Q
Q
q
q
0 1 -1 0 13 302.38 cm
/Xi0 Do
Q
q
1 0 0 1 452.41 676.53 cm
/Xi1 Do
Q
q
1 0 0 1 452.7 666.53 cm
/Xi2 Do
Q
q
1 0 0 1 490.7 666.53 cm
/Xi3 Do
Q
Q
Q
endstream
endobj
17 0 obj
<<
/Metadata 18 0 R
/Creator (Adobe Acrobat 7\0560)
/Title (logo1\056pdf)
>>
endobj
18 0 obj
<<
/Length 419
/Filter /FlateDecode
>>
stream
h얱n0w?Ł]+Q"$ " 4I;)RhHu#JY ; N#nJ+)tzZFj!ߊOo|@$mi[VtR隶b¬$.J6C.0V,>%04WxiD(rCɌNO bM,ЛsŸin0IG1WOXK/rҹ5E
{ٹcMMj :<4rSb$܉ ]Xɜƨo{έY17a˒/|a쳆V;"8JR{&pJgb\)FӛkSl +QŅ(~KE'?9#d2BF tX^kWӿ .
endstream
endobj
19 0 obj
<<
/Metadata 20 0 R
>>
endobj
20 0 obj
<<
/Length 3391
/Type /Metadata
/Subtype /XML
>>
stream
2012-07-25T16:46:54+05:30
2012-07-25T16:46:54+05:30
2012-07-25T16:46:54+05:30
uuid:BF80B53D4AD6E111A13FFA21AA81EDC9
uuid:BF80B53D4AD6E111A13FFA21AA81EDC9
uuid:2f230150-e450-4f82-a679-2033e737c72d
uuid:8f69fff1-bcbc-4f94-97e1-922aa97b7a30
application/eps
endstream
endobj
21 0 obj
[ /ICCBased 22 0 R ]
endobj
22 0 obj
<<
/Length 2598
/N 3
/Filter /FlateDecode
/Alternate /DeviceRGB
>>
stream
hޜwTTϽwz0z.0. Qf Ml@DEHb!(`HPb0dFJ|yyǽgs{. $O./ 'z8WGб x 0Y驾A@$/7z HeOOҬT _lN:K"N3"$F/JPrb[䥟}Qd[Sl1x{#bG\NoX3I[ql2 $8xtr p/8pCfq.Knjm͠{r28?.)ɩL^6 g,qm"[Z[Z~Q7%"
3R `̊j[~ : w! $E}kyhyRm333:
}=#vʉe
tqX)I)B>==
<8Xȉ9